Cyclooxygenase-Inhibiting Drug Effects on Skeletal Muscle Exercise Adaptations in Older Adults: Potential Mechanisms of Action

PURPOSE: To further investigate the mechanism of action of these drugs. METHODS: Vastus lateralis biopsies obtained before and ~72h following the last training bout were analyzed for mRNA levels of components of the COX pathway (arachidonic acid synthesis: cPLA sub(2) and sPLA sub(2)-X; prostaglandi...

Full description

Saved in:
Bibliographic Details
Published in:Medicine and science in sports and exercise 2012-05, Vol.44 (5S), p.355-355
Main Authors: Standley, Robert A, Jemiolo, Bozena, Carroll, Chad C, Trappe, Scott W, Trappe, Todd A
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PURPOSE: To further investigate the mechanism of action of these drugs. METHODS: Vastus lateralis biopsies obtained before and ~72h following the last training bout were analyzed for mRNA levels of components of the COX pathway (arachidonic acid synthesis: cPLA sub(2) and sPLA sub(2)-X; prostaglandin (PG)F sub(2 alpha ) synthesis: AKR1C3 and CBR1; PGE sub(2) synthesis: PTGES, PTGES-2; PGF sub(2 alpha ) and PGE sub(2) receptors: FP and EP4), regulators of muscle proteolysis (MuRF-1, Atrogin-1, FOXO3A, IKK beta ) and growth (Myogenin, MRF4, myostatin), and cytokines involved in skeletal muscle adaptation (TNF- alpha , IL-1 beta , IL-6, IL-8, IL-10). RESULTS: Several components were increased with training (cPLA sub(2), AKR1C3, CBR1, EP4, IKK beta , TNF- alpha , IL-1 beta , IL-8). However, IL-6, IL-10, and MuRF-1 were differentially upregulated (P
ISSN:0195-9131