Factors associated with non-adherence to antiretroviral therapy in adults with AIDS in the first six months of treatment in Salvador, Bahia State, Brazil

The control of viral replication is essential in the highly active antiretroviral therapy (HAART), and adherence to therapy is instrumental for such control. Individual and external factors influence adhesion to the use of antiretroviral (ARV) drugs. This is a cross-sectional study to investigate fa...

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Bibliographic Details
Published in:Cadernos de saúde pública 2015-06, Vol.31 (6), p.1188-1198
Main Authors: Silva, José Adriano Góes, Dourado, Inês, Brito, Ana Maria de, Silva, Carlos Alberto Lima da
Format: Article
Language:eng ; por
Subjects:
Acquired Immunodeficiency Syndrome - drug therapy
Adolescent
Adult
Age Factors
Anti-HIV Agents - therapeutic use
Antiretroviral Therapy, Highly Active
Brazil
Cross-Sectional Studies
Female
HIV Infections - drug therapy
Humans
Male
Medication Adherence - statistics & numerical data
Patient Compliance
Sex Factors
Socioeconomic Factors
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Summary:The control of viral replication is essential in the highly active antiretroviral therapy (HAART), and adherence to therapy is instrumental for such control. Individual and external factors influence adhesion to the use of antiretroviral (ARV) drugs. This is a cross-sectional study to investigate factors associated with non-adherence to HAART in AIDS patients in Salvador, Bahia State, Brazil, with age ≥ 13 years and first prescription in 2009. Data was collected from patient charts and pharmacy records. From a total of 216 patients, 65.3% were males; mean age 37.8 ± 9.5 years; single, 67.9%; heterosexual, 64%; more than 8 years of school education, 65.3%; alcohol users, 61.5%; non-smokers, 75,1% or non-illicit drug users, 93.7%. A proportion of 94% started ARV therapy with TCD4+ < 350 cells/mm3; 61.8% were symptomatic; and 68.4% had an adverse drug reaction. The prevalence of non-adherence was 25%. The variables associated were: longer time between HIV infection and AIDS (aOR = 3.9), adverse drug reaction (aOR = 2.4), under 34 years of age (aOR = 2.2), less than 8 years of school education (aOR = 2.2) and illicit drugs use (aOR = 2.6). A high-non-adherence rate is an important problem within the first six months of HAART.
ISSN:1678-4464
DOI:10.1590/0102-311X00106914