Prevalence of celiac disease in patients with severe food allergy

The association between food allergy and celiac disease (CD) is still to be clarified. We screened for CD 319 patients with severe food allergy (IgE > 85 kU/l against food proteins and a history of severe allergic reactions) who underwent specific food oral immunotherapy (OIT), together with 128...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2015-10, Vol.70 (10), p.1346-1349
Main Authors: Pillon, R., Ziberna, F., Badina, L., Ventura, A., Longo, G., Quaglia, S., De Leo, L., Vatta, S., Martelossi, S., Patano, G., Not, T., Berti, I.
Format: Article
Language:English
Subjects:
Adolescent
Autoantibodies - immunology
Celiac disease
Celiac Disease - complications
Celiac Disease - diagnosis
Celiac Disease - epidemiology
Celiac Disease - etiology
Child
Child, Preschool
Desensitization, Immunologic
Female
Food - adverse effects
Food allergies
Food Hypersensitivity - complications
Food Hypersensitivity - epidemiology
Food Hypersensitivity - immunology
Food Hypersensitivity - therapy
gluten–free diet
HLA-DQ Antigens - genetics
HLA-DQ Antigens - immunology
Humans
Immunotherapy
Male
Medical screening
Prevalence
severe food allergy
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Summary:The association between food allergy and celiac disease (CD) is still to be clarified. We screened for CD 319 patients with severe food allergy (IgE > 85 kU/l against food proteins and a history of severe allergic reactions) who underwent specific food oral immunotherapy (OIT), together with 128 children with mild allergy who recovered without OIT, and compared the prevalence data with our historical data regarding healthy schoolchildren. Sixteen patients (5%) with severe allergy and one (0.8%) with mild allergy tested positive for both genetic and serological CD markers, while the prevalence among the schoolchildren was 1%. Intestinal biopsies were obtained in 13/16 patients with severe allergy and in the one with mild allergy, confirming the diagnosis of CD. Sufferers from severe food allergy seem to be at a fivefold increased risk of CD. Our findings suggest that routine screening for CD should be recommended in patients with severe food allergy.
ISSN:0105-4538
1398-9995
DOI:10.1111/all.12692