Electrical impedance myography in duchenne muscular dystrophy and healthy controls: A multicenter study of reliability and validity

ABSTRACT Introduction: Electrical impedance myography (EIM) is a non‐invasive, painless, objective technique to quantify muscle pathology. Methods: We measured EIM in 8 arm and leg muscles in 61 boys with Duchenne muscular dystrophy (DMD) and 31 healthy boys, ages 3–12 years, at 5 centers. We determ...

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Bibliographic Details
Published in:Muscle & nerve 2015-10, Vol.52 (4), p.592-597
Main Authors: Zaidman, Craig M., Wang, Lucy L., Connolly, Anne M., Florence, Julaine, Wong, Brenda L., Parsons, Julie A., Apkon, Susan, Goyal, Namita, Williams, Eugene, Escolar, Diana, Rutkove, Seward B., Bohorquez, Jose L.
Format: Article
Language:English
Subjects:
Age Factors
biomarker
Child
Child, Preschool
children
Duchenne muscular dystrophy
Electric Impedance
electrical impedance myography
Female
Humans
Male
Muscle Strength - physiology
Muscle Strength Dynamometer
Muscle, Skeletal - physiopathology
Muscular Dystrophy, Duchenne - pathology
Muscular Dystrophy, Duchenne - physiopathology
Myography
myopathy
Reproducibility of Results
ROC Curve
Severity of Illness Index
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Summary:ABSTRACT Introduction: Electrical impedance myography (EIM) is a non‐invasive, painless, objective technique to quantify muscle pathology. Methods: We measured EIM in 8 arm and leg muscles in 61 boys with Duchenne muscular dystrophy (DMD) and 31 healthy boys, ages 3–12 years, at 5 centers. We determined the reliability of EIM and compared results in boys with DMD to controls and to 6‐minute walk distance (6MWD), North Star Ambulatory Assessment (NSAA), timed functional tests (TFTs), and strength (hand‐held dynamometry). Results: EIM was well tolerated and had good inter‐ and intrarater reliability (intraclass correlation coefficient 0.81–0.96). The averaged EIM phase value from all muscles was higher (P 
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.24611