The Cellular and Molecular Basis of Translational Immunometabolism

The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions. Immune cell metabolism has therefore become an attrac...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2015-09, Vol.43 (3), p.421-434
Main Authors: Norata, Giuseppe Danilo, Caligiuri, Giuseppina, Chavakis, Triantafyllos, Matarese, Giuseppe, Netea, Mihai Gheorge, Nicoletti, Antonino, O’Neill, Luke A.J., Marelli-Berg, Federica M.
Format: Article
Language:English
Subjects:
Animals
Cholesterol
Energy Metabolism - genetics
Energy Metabolism - immunology
Humans
Immune System - cytology
Immune System - immunology
Immune System - metabolism
Lipids
Macrophages - immunology
Macrophages - metabolism
Metabolic Diseases - genetics
Metabolic Diseases - immunology
Metabolic Diseases - metabolism
Metabolic disorders
Metabolic Networks and Pathways - genetics
Metabolic Networks and Pathways - immunology
Metabolites
Models, Immunological
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
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Summary:The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions. Immune cell metabolism has therefore become an attractive target area for therapeutic purposes. A neglected aspect in the translation of immunometabolism is the critical connection between systemic and cellular metabolism. Here, we discuss the importance of understanding and manipulating the integration of systemic and immune cell metabolism through in-depth analysis of immune cell phenotype and function in human metabolic diseases and, in parallel, of the effects of conventional metabolic drugs on immune cell differentiation and function. We examine how the recent identification of selective metabolic programs operating in distinct immune cell subsets and functions has the potential to deliver tools for cell- and function-specific immunometabolic targeting. How the energy demands of immune cells are affected by systemic metabolism in homeostasis and disease is unclear. Here, Norata and colleagues propose a working model to understand and therapeutically manipulate the integration of systemic and immune cell metabolism.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2015.08.023