Autonomic neuropathy resulting in recurrent laryngeal nerve palsy in an HIV patient with Hodgkin lymphoma receiving vinblastine and antiretroviral therapy

Hoarseness of voice due to vocal cord paresis as a result of recurrent laryngeal nerve palsy has been well recognised. Recurrent laryngeal nerve palsy is commonly caused by compression due to tumour or lymph nodes or by surgical damage. Vinca alkaloids are well known to cause peripheral neuropathy....

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Bibliographic Details
Published in:International journal of STD & AIDS 2015-03, Vol.26 (3), p.206-208
Main Authors: Cherif, S, Danino, S, Yoganathan, K
Format: Article
Language:English
Subjects:
AIDS/HIV
Antineoplastic Agents, Phytogenic - adverse effects
Antineoplastic Agents, Phytogenic - therapeutic use
Antiretroviral Therapy, Highly Active
Biopsy
HIV Infections - complications
HIV Infections - drug therapy
Hoarseness - diagnosis
Hoarseness - diagnostic imaging
Hoarseness - etiology
Hoarseness - surgery
Hodgkin Disease - complications
Hodgkin Disease - drug therapy
Human immunodeficiency virus
Humans
Male
Middle Aged
Positron-Emission Tomography
Radiography
Recurrent Laryngeal Nerve Injuries
Treatment Outcome
Vinblastine - adverse effects
Vinblastine - therapeutic use
Vinca
Vocal Cord Paralysis - chemically induced
Vocal Cord Paralysis - complications
Vocal Cords - diagnostic imaging
Vocal Cords - innervation
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Summary:Hoarseness of voice due to vocal cord paresis as a result of recurrent laryngeal nerve palsy has been well recognised. Recurrent laryngeal nerve palsy is commonly caused by compression due to tumour or lymph nodes or by surgical damage. Vinca alkaloids are well known to cause peripheral neuropathy. However, vinca alkaloids causing recurrent laryngeal nerve palsy has been reported rarely in children. We report a case of an adult patient with HIV who developed hoarseness of voice due to vocal cord paralysis during vinblastine treatment for Hodgkin lymphoma. Mediastinal and hilar lymph node enlargement in such patients may distract clinicians from considering alternative causes of recurrent laryngeal nerve palsy, with potential ensuing severe or even life-threatening stridor.
ISSN:0956-4624
1758-1052
DOI:10.1177/0956462414534396