Calcium signaling and cell proliferation

Cell proliferation is orchestrated through diverse proteins related to calcium (Ca2+) signaling inside the cell. Cellular Ca2+ influx that occurs first by various mechanisms at the plasma membrane, is then followed by absorption of Ca2+ ions by mitochondria and endoplasmic reticulum, and, finally, t...

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Bibliographic Details
Published in:Cellular signalling 2015-11, Vol.27 (11), p.2139-2149
Main Authors: Pinto, Mauro Cunha Xavier, Kihara, Alexandre Hiroaki, Goulart, Vânia A.M., Tonelli, Fernanda M.P., Gomes, Katia N., Ulrich, Henning, Resende, Rodrigo R.
Format: Article
Language:English
Subjects:
Animals
Ca2 + signaling
Calcium - metabolism
Calcium channels
Calcium Channels - metabolism
Calcium Signaling - physiology
Cell Membrane - metabolism
Cell Nucleus - metabolism
cell proliferation
Cell Proliferation - physiology
CRAC
Endoplasmic Reticulum - metabolism
Humans
Membrane Proteins - metabolism
Mitochondria - metabolism
Orai1
SOCE
STIM
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Summary:Cell proliferation is orchestrated through diverse proteins related to calcium (Ca2+) signaling inside the cell. Cellular Ca2+ influx that occurs first by various mechanisms at the plasma membrane, is then followed by absorption of Ca2+ ions by mitochondria and endoplasmic reticulum, and, finally, there is a connection of calcium stores to the nucleus. Experimental evidence indicates that the fluctuation of Ca2+ from the endoplasmic reticulum provides a pivotal and physiological role for cell proliferation. Ca2+ depletion in the endoplasmatic reticulum triggers Ca2+ influx across the plasma membrane in an phenomenon called store-operated calcium entries (SOCEs). SOCE is activated through a complex interplay between a Ca2+ sensor, denominated STIM, localized in the endoplasmic reticulum and a Ca2+ channel at the cell membrane, denominated Orai. The interplay between STIM and Orai proteins with cell membrane receptors and their role in cell proliferation is discussed in this review. [Display omitted] •Mechanisms of cytosolic Ca2+ entry in cell proliferation•STIM proteins and cell proliferation•Orai proteins and cell proliferation•Ca2+ signaling and gene transcription
ISSN:0898-6568
1873-3913
DOI:10.1016/j.cellsig.2015.08.006