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Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls
Highlights • Developed a novel plasma genomic abnormality (PGA) score for CNV analysis. • Demonstrated potential use of PGA scores in early detection of lung cancer. • Showed detectable gene mutations in early stage lung cancer.
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| Published in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2015-10, Vol.90 (1), p.78-84 |
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| Main Authors: | , , , , , , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c420t-b497e236e38ac083c9a72c48edbe62b4b60025d3fb57a2e29b031a179bff57823 |
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| cites | cdi_FETCH-LOGICAL-c420t-b497e236e38ac083c9a72c48edbe62b4b60025d3fb57a2e29b031a179bff57823 |
| container_end_page | 84 |
| container_issue | 1 |
| container_start_page | 78 |
| container_title | Lung cancer (Amsterdam, Netherlands) |
| container_volume | 90 |
| creator | Xia, Shu Huang, Chiang-Ching Le, Min Dittmar, Rachel Du, Meijun Yuan, Tiezheng Guo, Yongchen Wang, Yuan Wang, Xuexia Tsai, Susan Suster, Saul Mackinnon, Alexander C Wang, Liang |
| description | Highlights • Developed a novel plasma genomic abnormality (PGA) score for CNV analysis. • Demonstrated potential use of PGA scores in early detection of lung cancer. • Showed detectable gene mutations in early stage lung cancer. |
| doi_str_mv | 10.1016/j.lungcan.2015.07.002 |
| format | article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-b497e236e38ac083c9a72c48edbe62b4b60025d3fb57a2e29b031a179bff57823</citedby><cites>FETCH-LOGICAL-c420t-b497e236e38ac083c9a72c48edbe62b4b60025d3fb57a2e29b031a179bff57823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26233568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xia, Shu</creatorcontrib><creatorcontrib>Huang, Chiang-Ching</creatorcontrib><creatorcontrib>Le, Min</creatorcontrib><creatorcontrib>Dittmar, Rachel</creatorcontrib><creatorcontrib>Du, Meijun</creatorcontrib><creatorcontrib>Yuan, Tiezheng</creatorcontrib><creatorcontrib>Guo, Yongchen</creatorcontrib><creatorcontrib>Wang, Yuan</creatorcontrib><creatorcontrib>Wang, Xuexia</creatorcontrib><creatorcontrib>Tsai, Susan</creatorcontrib><creatorcontrib>Suster, Saul</creatorcontrib><creatorcontrib>Mackinnon, Alexander C</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><title>Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls</title><title>Lung cancer (Amsterdam, Netherlands)</title><addtitle>Lung Cancer</addtitle><description>Highlights • Developed a novel plasma genomic abnormality (PGA) score for CNV analysis. • Demonstrated potential use of PGA scores in early detection of lung cancer. • Showed detectable gene mutations in early stage lung cancer.</description><subject>Adenocarcinoma - blood</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma of Lung</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Allele-specific PCR</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Case-Control Studies</subject><subject>cfDNA</subject><subject>Copy number variations</subject><subject>Digital PCR</subject><subject>DNA Copy Number Variations - genetics</subject><subject>DNA Mutational Analysis - instrumentation</subject><subject>DNA Mutational Analysis - methods</subject><subject>DNA, Neoplasm - blood</subject><subject>DNA, Neoplasm - genetics</subject><subject>Female</subject><subject>Genetic Variation</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>High-Throughput Nucleotide Sequencing - methods</subject><subject>Humans</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Neoplasm Staging</subject><subject>Next generation sequencing</subject><subject>Non-small cell lung cancer</subject><subject>Plasma</subject><subject>Plasma Cells - metabolism</subject><subject>Plasma Cells - pathology</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Pulmonary/Respiratory</subject><issn>0169-5002</issn><issn>1872-8332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkUtv1DAURi0EokPhJ4C8ZJPgRxw7G1BVoEWqYAGsLce5rjw49mAnlebf42imLNiwsmSd-_jOReg1JS0ltH-3b8Ma762JLSNUtES2hLAnaEeVZI3inD1Fu8oNjaj_F-hFKXtCqKRkeI4uWM84F73aIXcDMc3e4geTvVl8igX7iA_BlNlgCyFglwHwx69XePLOQYa4VBAwmByOuCzmHvC2Cq67WMil8mnGMeXZBGxTXHIK5SV65kwo8Or8XqKfnz_9uL5t7r7dfLm-umtsx8jSjN0ggfEeuDKWKG4HI5ntFEwj9Gzsxr6GERN3o5CGARtGwqmhchidE1Ixfonenvoecvq9Qln07MuWwkRIa9GbgF70kncVFSfU5lRKBqcP2c8mHzUlelOs9_qsWG-KNZG6Tq91b84j1nGG6W_Vo9MKfDgBUIM-eMi6WA_VzeQz2EVPyf93xPt_Otjgo7cm_IIjlH1ac6wWNdWFaaK_b3fezkwFJ4Qoxf8ATPelFQ</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Xia, Shu</creator><creator>Huang, Chiang-Ching</creator><creator>Le, Min</creator><creator>Dittmar, Rachel</creator><creator>Du, Meijun</creator><creator>Yuan, Tiezheng</creator><creator>Guo, Yongchen</creator><creator>Wang, Yuan</creator><creator>Wang, Xuexia</creator><creator>Tsai, Susan</creator><creator>Suster, Saul</creator><creator>Mackinnon, Alexander C</creator><creator>Wang, Liang</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151001</creationdate><title>Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls</title><author>Xia, Shu ; Huang, Chiang-Ching ; Le, Min ; Dittmar, Rachel ; Du, Meijun ; Yuan, Tiezheng ; Guo, Yongchen ; Wang, Yuan ; Wang, Xuexia ; Tsai, Susan ; Suster, Saul ; Mackinnon, Alexander C ; Wang, Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-b497e236e38ac083c9a72c48edbe62b4b60025d3fb57a2e29b031a179bff57823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma - blood</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma of Lung</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Allele-specific PCR</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Case-Control Studies</topic><topic>cfDNA</topic><topic>Copy number variations</topic><topic>Digital PCR</topic><topic>DNA Copy Number Variations - genetics</topic><topic>DNA Mutational Analysis - instrumentation</topic><topic>DNA Mutational Analysis - methods</topic><topic>DNA, Neoplasm - blood</topic><topic>DNA, Neoplasm - genetics</topic><topic>Female</topic><topic>Genetic Variation</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>High-Throughput Nucleotide Sequencing - methods</topic><topic>Humans</topic><topic>Lung Neoplasms - blood</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Neoplasm Staging</topic><topic>Next generation sequencing</topic><topic>Non-small cell lung cancer</topic><topic>Plasma</topic><topic>Plasma Cells - metabolism</topic><topic>Plasma Cells - pathology</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Pulmonary/Respiratory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xia, Shu</creatorcontrib><creatorcontrib>Huang, Chiang-Ching</creatorcontrib><creatorcontrib>Le, Min</creatorcontrib><creatorcontrib>Dittmar, Rachel</creatorcontrib><creatorcontrib>Du, Meijun</creatorcontrib><creatorcontrib>Yuan, Tiezheng</creatorcontrib><creatorcontrib>Guo, Yongchen</creatorcontrib><creatorcontrib>Wang, Yuan</creatorcontrib><creatorcontrib>Wang, Xuexia</creatorcontrib><creatorcontrib>Tsai, Susan</creatorcontrib><creatorcontrib>Suster, Saul</creatorcontrib><creatorcontrib>Mackinnon, Alexander C</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xia, Shu</au><au>Huang, Chiang-Ching</au><au>Le, Min</au><au>Dittmar, Rachel</au><au>Du, Meijun</au><au>Yuan, Tiezheng</au><au>Guo, Yongchen</au><au>Wang, Yuan</au><au>Wang, Xuexia</au><au>Tsai, Susan</au><au>Suster, Saul</au><au>Mackinnon, Alexander C</au><au>Wang, Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>90</volume><issue>1</issue><spage>78</spage><epage>84</epage><pages>78-84</pages><issn>0169-5002</issn><eissn>1872-8332</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Highlights • Developed a novel plasma genomic abnormality (PGA) score for CNV analysis. • Demonstrated potential use of PGA scores in early detection of lung cancer. • Showed detectable gene mutations in early stage lung cancer.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>26233568</pmid><doi>10.1016/j.lungcan.2015.07.002</doi><tpages>7</tpages></addata></record> |
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| subjects | Adenocarcinoma - blood Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Aged Aged, 80 and over Allele-specific PCR Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Case-Control Studies cfDNA Copy number variations Digital PCR DNA Copy Number Variations - genetics DNA Mutational Analysis - instrumentation DNA Mutational Analysis - methods DNA, Neoplasm - blood DNA, Neoplasm - genetics Female Genetic Variation Hematology, Oncology and Palliative Medicine High-Throughput Nucleotide Sequencing - methods Humans Lung Neoplasms - blood Lung Neoplasms - genetics Lung Neoplasms - pathology Male Middle Aged Mutation Neoplasm Staging Next generation sequencing Non-small cell lung cancer Plasma Plasma Cells - metabolism Plasma Cells - pathology Polymerase Chain Reaction - methods Pulmonary/Respiratory |
| title | Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls |
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