Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls

Highlights • Developed a novel plasma genomic abnormality (PGA) score for CNV analysis. • Demonstrated potential use of PGA scores in early detection of lung cancer. • Showed detectable gene mutations in early stage lung cancer.

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2015-10, Vol.90 (1), p.78-84
Main Authors: Xia, Shu, Huang, Chiang-Ching, Le, Min, Dittmar, Rachel, Du, Meijun, Yuan, Tiezheng, Guo, Yongchen, Wang, Yuan, Wang, Xuexia, Tsai, Susan, Suster, Saul, Mackinnon, Alexander C, Wang, Liang
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adenocarcinoma of Lung
Aged
Aged, 80 and over
Allele-specific PCR
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
Case-Control Studies
cfDNA
Copy number variations
Digital PCR
DNA Copy Number Variations - genetics
DNA Mutational Analysis - instrumentation
DNA Mutational Analysis - methods
DNA, Neoplasm - blood
DNA, Neoplasm - genetics
Female
Genetic Variation
Hematology, Oncology and Palliative Medicine
High-Throughput Nucleotide Sequencing - methods
Humans
Lung Neoplasms - blood
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Middle Aged
Mutation
Neoplasm Staging
Next generation sequencing
Non-small cell lung cancer
Plasma
Plasma Cells - metabolism
Plasma Cells - pathology
Polymerase Chain Reaction - methods
Pulmonary/Respiratory
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Description
Summary:Highlights • Developed a novel plasma genomic abnormality (PGA) score for CNV analysis. • Demonstrated potential use of PGA scores in early detection of lung cancer. • Showed detectable gene mutations in early stage lung cancer.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2015.07.002