Recovery of brain acetylcholinesterase and plasma cholinesterase activities in quail (Coturnix coturnix) after chlorpyriphos administration and effect of pralidoxime treatment

Chlorpyriphos (13 mg/kg) was administered to quail (Coturnix coturnix), and the responses of brain acetylcholinesterase (AChE) and plasma cholinesterase (ChE) were studied. Both enzymes responded rapidly, and the maximal inhibition (76.6 and 86.1%, respectively) ocurred 8 h postadministration. Plasm...

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Bibliographic Details
Published in:Environmental toxicology and chemistry 1998-09, Vol.17 (9), p.1835-1839
Main Authors: Soler-Rodriguez, F. (Universidad de Extremadura, Caceres, Spain.), Miguez-Santiyan, M.P, Reja-Sanchez, A, Roncero-Cordero, V, Garcia-Cambero, J.P
Format: Article
Language:English
Subjects:
ACTIVIDAD ENZIMATICA
ACTIVITE ENZYMATIQUE
Animal, plant and microbial ecology
Applied ecology
Aves
Biological and medical sciences
BLOOD PLASMA
BRAIN
CAILLE
CEREBRO
CHLORPYRIFOS
Chlorpyriphos
Cholinesterase
CLORPIRIFOS
CODORNIZ
Coturnix coturnix
Ecotoxicology, biological effects of pollution
Effects of pollution and side effects of pesticides on vertebrates
ENCEPHALE
ENZYMIC ACTIVITY
Fundamental and applied biological sciences. Psychology
INHIBICION
INHIBITION
PLASMA SANGUIN
PLASMA SANGUINEO
Pralidoxime
Quail
QUAILS
TOXICOLOGIA
TOXICOLOGIE
TOXICOLOGY
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Summary:Chlorpyriphos (13 mg/kg) was administered to quail (Coturnix coturnix), and the responses of brain acetylcholinesterase (AChE) and plasma cholinesterase (ChE) were studied. Both enzymes responded rapidly, and the maximal inhibition (76.6 and 86.1%, respectively) ocurred 8 h postadministration. Plasma ChE recovered rapidly, and even on day 4, ChE values of quail that had received chlorpyriphos were higher than those of controls. The recovery of brain AChE activity was slower than that of plasma; it reached 59% of controls 2 d after chlorpyriphos administration, then it recovered slowly, and only at day 11 was its level not depressed with respect to controls. This recovery followed the logarithmic pattern Y = a + b(log X), where Y is the AChE activity expressed as the percentage with respect to controls and X is the day after dosing, giving a significant correlation (r = 0.9746, p 0.001 when using group means and r
ISSN:0730-7268
1552-8618
DOI:10.1002/etc.5620170925