Mediastinal paraganglioma

We present a case of mediastinal paraganglioma with radiologic–pathologic correlation. A 48-year-old woman was found incidentally to have a middle mediastinal mass on CT. The mass showed iso-signal intensity compared to that of muscle on T1-weighted images and high signal intensity on T2-weighted im...

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Bibliographic Details
Published in:Japanese journal of radiology 2015-07, Vol.33 (7), p.433-436
Main Authors: Takashima, Yoko, Kamitani, Takeshi, Kawanami, Satoshi, Nagao, Michinobu, Yonezawa, Masato, Yamasaki, Yuzo, Baba, Shingo, Yabuuchi, Hidetake, Hida, Tomoyuki, Kohashi, Kenichi, Nakamura, Katsuya, Sonoda, Hiromichi, Oda, Yoshinao, Honda, Hiroshi
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Case Report
Diffusion Magnetic Resonance Imaging
Female
Fluorodeoxyglucose F18
Humans
Imaging
Magnetic Resonance Imaging
Mediastinal Neoplasms - diagnostic imaging
Mediastinal Neoplasms - pathology
Medicine
Medicine & Public Health
Middle Aged
Nuclear Medicine
Paraganglioma - diagnostic imaging
Paraganglioma - pathology
Positron-Emission Tomography
Radiology
Radiopharmaceuticals
Radiotherapy
Tomography, X-Ray Computed
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Summary:We present a case of mediastinal paraganglioma with radiologic–pathologic correlation. A 48-year-old woman was found incidentally to have a middle mediastinal mass on CT. The mass showed iso-signal intensity compared to that of muscle on T1-weighted images and high signal intensity on T2-weighted images. The lesion showed intermediate intensity on diffusion-weighted imaging, and its apparent diffusion coefficient was 1.72 × 10 −3 mm 2 /s. A contrast-enhanced dynamic study revealed a rapid peak and washout enhancement pattern. 18 F-FDG-PET revealed abnormal uptake in the mediastinal tumor with a maximal standardized uptake value of 7.88. 123 I-meta-iodobenzylguanidine scintigraphy also showed abnormal uptake in the tumor. These findings corresponded to the hypervascularity, rich stroma, low nuclear/cytoplasmic ratio, and nest-forming proliferation of tumor cells with positive neuroendocrine markers.
ISSN:1867-1071
1867-108X
DOI:10.1007/s11604-015-0436-z