Image-defined risk factor assessment of neurogenic tumors after neoadjuvant chemotherapy is useful for predicting intra-operative risk factors and the completeness of resection

Background Patients with neuroblastoma are now stratified at diagnosis according to the presence and number of image‐defined risk factors (IDRFs). We examined the added value of IDRF assessment after neoadjuvant chemotherapy for predicting surgical resection. Material and Methods From 2009–2012, 39...

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Published in:Pediatric blood & cancer 2015-09, Vol.62 (9), p.1543-1549
Main Authors: Irtan, Sabine, Brisse, Hervé J, Minard-Colin, Véronique, Schleiermacher, Gudrun, Galmiche-Rolland, Louise, Le Cossec, Chloé, Elie, Caroline, Canale, Sandra, Michon, Jean, Valteau-Couanet, Dominique, Sarnacki, Sabine
Format: Article
Language:English
Subjects:
Abdominal Neoplasms - diagnostic imaging
Abdominal Neoplasms - drug therapy
Abdominal Neoplasms - epidemiology
Abdominal Neoplasms - pathology
Abdominal Neoplasms - surgery
Adolescent
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carboplatin - administration & dosage
Child
Child, Preschool
Combined Modality Therapy
Cyclophosphamide - administration & dosage
Diagnostic Imaging - methods
Etoposide - administration & dosage
Female
Ganglioneuroblastoma - diagnostic imaging
Ganglioneuroblastoma - drug therapy
Ganglioneuroblastoma - epidemiology
Ganglioneuroblastoma - pathology
Ganglioneuroblastoma - surgery
Hematology
Hematopoietic Stem Cell Transplantation
Humans
IDRF
Infant
Kaplan-Meier Estimate
Magnetic Resonance Imaging
Male
Neoadjuvant Therapy
Neoplasm Staging
Neoplasm, Residual
neuroblastoma
Neuroblastoma - diagnostic imaging
Neuroblastoma - drug therapy
Neuroblastoma - epidemiology
Neuroblastoma - pathology
Neuroblastoma - surgery
Oncology
Pediatrics
Postoperative Complications - epidemiology
Postoperative Complications - prevention & control
Risk Assessment
Risk Factors
surgical complications
Thoracic Neoplasms - diagnostic imaging
Thoracic Neoplasms - drug therapy
Thoracic Neoplasms - epidemiology
Thoracic Neoplasms - pathology
Thoracic Neoplasms - surgery
Tomography, X-Ray Computed
Treatment Outcome
Vincristine - administration & dosage
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Summary:Background Patients with neuroblastoma are now stratified at diagnosis according to the presence and number of image‐defined risk factors (IDRFs). We examined the added value of IDRF assessment after neoadjuvant chemotherapy for predicting surgical resection. Material and Methods From 2009–2012, 39 out of 91 patients operated on in our institution for neuroblastic tumors received neoadjuvant chemotherapy based on ongoing SIOPEN protocols or treatment guidelines. IDRFs were assessed both at diagnosis and preoperatively on CT and/or MRI. Results Median age at diagnosis was 30 months [range 2–191]. The tumor locations were adrenal (n = 20), paravertebral (n = 13) and perivascular (n = 6). INRGSS stages were L2 (n = 13), M (n = 25) and Ms (n = 1). Eleven tumors (28%) were MYCN‐amplified. Chemotherapy reduced the number of IDRFs in 54% of patients overall (21/39): 61.5% (16/26) of M and Ms patients, and 38.5% (5/13) of non metastatic patients (P 
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.25511