Usefulness of Cardiac Troponins as Markers of Early Treatment Response in Cardiac Sarcoidosis

Evaluation and treatment of cardiac sarcoidosis (CS) suffer from lack of sensitive and easily repeatable markers of disease activity. We studied measurements of high-sensitivity cardiac troponin T or troponin I (hs-cTnT/I) taken at presentation and during treatment in 62 patients with new-onset CS (...

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Bibliographic Details
Published in:The American journal of cardiology 2015-09, Vol.116 (6), p.960-964
Main Authors: Kandolin, Riina, MD, Lehtonen, Jukka, MD, Airaksinen, Juhani, MD, Vihinen, Tapani, MD, Miettinen, Heikki, MD, Kaikkonen, Kari, MD, Haataja, Petri, MD, Kerola, Tuomas, MD, Kupari, Markku, MD
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Cardiology
Cardiomyopathies - blood
Cardiomyopathies - drug therapy
Cardiovascular
Female
Glucocorticoids - therapeutic use
Heart attacks
Humans
Male
Middle Aged
NMR
Nuclear magnetic resonance
Prednisone - therapeutic use
Prognosis
Sarcoidosis - blood
Sarcoidosis - drug therapy
Studies
Treatment Outcome
Troponin I - blood
Troponin T - blood
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Summary:Evaluation and treatment of cardiac sarcoidosis (CS) suffer from lack of sensitive and easily repeatable markers of disease activity. We studied measurements of high-sensitivity cardiac troponin T or troponin I (hs-cTnT/I) taken at presentation and during treatment in 62 patients with new-onset CS (48 women, mean age 49 years). Hs-cTnT was measured in 50 patients and was elevated (>13 ng/L) at presentation in 26 of them (52%). Hs-cTnI was measured in the remaining 12 patients and was elevated (>0.04 ng/mL) in 7 of them (58%). Left ventricular ejection fraction averaged 43 ± 14% in association with elevated hs-cTnT/I (n = 33) versus 53 ± 10% with normal hs-cTnT/I (n = 29; p = 0.001). Hs-cTnT/I was remeasured after 4 weeks of steroid therapy in 38 patients and was normalized in 16 of the 24 (67%) with an elevated pretreatment concentration and remained normal in the rest of the 14 patients (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2015.06.021