Multiple cerebral infarctions in a young patient with heroin-induced hypereosinophilic syndrome

Hypereosinophilic syndrome represents a rare cause for cerebral infarctions and inflammatory neurological disorders. Various possible pathogenic mechanisms for cerebral infarctions have already been discussed. Complex mechanisms including a local hypercoagulability by eosinophilic granules as well a...

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Bibliographic Details
Published in:Journal of the neurological sciences 2015-09, Vol.356 (1), p.193-195
Main Authors: Bolz, Jan, Meves, Saskia H, Kara, Kaffer, Reinacher-Schick, Anke, Gold, Ralf, Krogias, Christos
Format: Article
Language:English
Subjects:
Adult
Cerebral Infarction - diagnosis
Cerebral Infarction - etiology
Cerebrovascular disease
Heroin
Heroin - adverse effects
Humans
Hypereosinophilic Syndrome
Hypereosinophilic Syndrome - chemically induced
Hypereosinophilic Syndrome - complications
Magnetic Resonance Imaging
Male
MRI
Neurology
Stroke
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Summary:Hypereosinophilic syndrome represents a rare cause for cerebral infarctions and inflammatory neurological disorders. Various possible pathogenic mechanisms for cerebral infarctions have already been discussed. Complex mechanisms including a local hypercoagulability by eosinophilic granules as well as a direct damage to endothelial cells, leading to alterations of the microcirculation seem to be involved. The changing pattern of heroin use to inhalation/sniffing leading to an increasing abuse may cause a rise in the prevalence of Heroin induced eosinophilia, as it has been reported in a case of eosinophilic pneumonia associated with heroin inhalation. To our knowledge, the present case report displays the first description of stroke in the setting of heroin induced hypereosinophilia. Thus, besides usual vasoconstriction, HES should be considered in drug-induced cerebral infarctions.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2015.06.031