Highly increased risk of type 2 diabetes in patients with binge eating disorder and bulimia nervosa

ABSTRACT Objective We aimed to examine the prevalence and incidence of type 2 diabetes (T2D) in a large patient cohort treated for binge eating disorder (BED), bulimia nervosa (BN), and anorexia nervosa. Method Patients (N = 2,342) treated at the Eating Disorder Unit of Helsinki University Central H...

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Bibliographic Details
Published in:The International journal of eating disorders 2015-09, Vol.48 (6), p.555-562
Main Authors: Raevuori, Anu, Suokas, Jaana, Haukka, Jari, Gissler, Mika, Linna, Milla, Grainger, Marjut, Suvisaari, Jaana
Format: Article
Language:English
Subjects:
Adolescent
Adult
Binge eating
Binge-Eating Disorder - complications
Binge-Eating Disorder - metabolism
Binge-Eating Disorder - therapy
Bulimia
Bulimia Nervosa - complications
Bulimia Nervosa - metabolism
Bulimia Nervosa - therapy
Cohort Studies
Diabetes
diabetes mellitus
diabetes mellitus type 2
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - metabolism
Eating disorders
Female
Glucose
glucose intolerance
Glucose Intolerance - complications
Glucose Intolerance - metabolism
Humans
Incidence
Male
Metabolism
Middle Aged
Prevalence
Risk
Risk factors
Young Adult
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Summary:ABSTRACT Objective We aimed to examine the prevalence and incidence of type 2 diabetes (T2D) in a large patient cohort treated for binge eating disorder (BED), bulimia nervosa (BN), and anorexia nervosa. Method Patients (N = 2,342) treated at the Eating Disorder Unit of Helsinki University Central Hospital over the period up to 16 years were compared with matched general population controls (N = 9,368) in three stages: before entering to the treatment for an eating disorder, after the entrance until the end of the study period, and combined any time before, during, and after the treatment. The study population was linked with the oral TSD medication data of 17 years from The Medical Reimbursement Register. Data were analyzed using conditional and Poisson regression models. Results Before entering to the treatment for eating disorders, the risk of T2D was substantially increased in patients compared with controls (OR 6.6, 95% CI 4.0–10.7). At the end of the study period, the lifetime prevalence of T2D was 5.2% among patients, 1.7% among controls (OR 3.4, 95% CI 2.6–4.4), and in male patients, it was significantly higher compared with females. Of those treated for BED, every third had T2D by the end of the study period (OR 12.9, 95% CI 7.4–22.5), whereas the same was true for 4.4% of those with BN (OR 2.4, 95% CI 1.7–3.5). Discussion Our findings provide strong support for the association between T2D and clinically significant binge eating. Disturbed glucose metabolism may contribute to the onset and maintenance of BED and BN. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:555–562)
ISSN:0276-3478
1098-108X
DOI:10.1002/eat.22334