Comparative study of hemodynamic changes caused by diazepam and midazolam during third molar surgery: a randomized controlled trial

The aim of the present study was to compare hemodynamic changes using midazolam 7.5 mg and diazepam 10.0 mg during the surgical removal of symmetrically positioned third molars. A prospective, randomized, double-blind, clinical trial was carried out involving 120 patients divided into three groups:...

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Bibliographic Details
Published in:Oral and maxillofacial surgery 2015-09, Vol.19 (3), p.267-273
Main Authors: de Morais, Hécio Henrique Araújo, Barbalho, Jimmy Charles Melo, de Holanda Vasconcellos, Ricardo José, Landim, Fabricio Souza, da Costa Araújo, Fábio Andrey, de Souza Dias, Tasiana Guedes
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anesthesia, Dental
Dental Anxiety - drug therapy
Dental Anxiety - psychology
Dentistry
Diazepam
Double-Blind Method
Drug Therapy, Combination
Female
Hemodynamics - drug effects
Humans
Male
Medicine
Medicine & Public Health
Midazolam
Molar, Third - surgery
Oral and Maxillofacial Surgery
Original Article
Pilot Projects
Tooth Extraction - psychology
Young Adult
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Summary:The aim of the present study was to compare hemodynamic changes using midazolam 7.5 mg and diazepam 10.0 mg during the surgical removal of symmetrically positioned third molars. A prospective, randomized, double-blind, clinical trial was carried out involving 120 patients divided into three groups: Group 1 (diazepam and placebo), Group 2 (midazolam and placebo), and Group 3 (diazepam and midazolam). Each subject underwent two surgeries on separate occasions under local anesthesia. The following parameters were assessed at five different times (T0, T1, T2, T3, and T4): systolic, diastolic, and mean blood pressure (SBP, DBP, and MBP, respectively); heart rate (HR); oxygen saturation (SpO 2 ); rate pressure product (RPP); and pressure rate quotient (PRQ). Statistically significant differences were found regarding heart rate at T2 and T3 ( p  
ISSN:1865-1550
1865-1569
DOI:10.1007/s10006-015-0488-3