Identifying the impact of inflammatory breast cancer on survival: a retrospective multi-center cohort study

Purpose Inflammatory breast cancer (IBC) represents a rare and aggressive form of cancer with negative prognosis and high rate of recurrence. The purpose of this retrospective multi-center study was to evaluate the effect of IBC on overall and disease-free survival. Furthermore we analyzed the influ...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2015-09, Vol.292 (3), p.655-664
Main Authors: Diessner, J., Van Ewijk, R., Weiss, C. R., Janni, W., Wischnewsky, M. B., Kreienberg, R., Hancke, K., Blettner, M., Wöckel, A., Schwentner, L.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast cancer
Cohort analysis
Disease-Free Survival
Endocrinology
Female
Germany - epidemiology
Gynecologic Oncology
Gynecology
Human Genetics
Humans
Incidence
Inflammatory Breast Neoplasms - diagnosis
Inflammatory Breast Neoplasms - metabolism
Inflammatory Breast Neoplasms - mortality
Kaplan-Meier Estimate
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local
Neoplasm Staging
Obstetrics/Perinatology/Midwifery
Prevalence
Prognosis
Proportional Hazards Models
Receptor, ErbB-2 - metabolism
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
Retrospective Studies
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Summary:Purpose Inflammatory breast cancer (IBC) represents a rare and aggressive form of cancer with negative prognosis and high rate of recurrence. The purpose of this retrospective multi-center study was to evaluate the effect of IBC on overall and disease-free survival. Furthermore we analyzed the influence of hormone and Her2 receptor expression on inflammatory breast cancer cells on the clinical outcome of patients. Methods This retrospective German multi-center study included 11,780 patients with primary breast cancer recruited from 1992 to 2008. In this sub-group analysis we focused on 70 patients with IBC. Results Despite the relatively small sample size, we could confirm the aggressiveness of inflammatory breast cancer and the different clinical behavior of IBC subtypes. It could be demonstrated that the lack of expression of hormone receptors on tumor cells is associated with a more aggressive clinical course and decreased overall and disease-free survival. Higher incidence of Her2 overexpression, that is typically associated with poor prognostic outcome among women with non-IBC tumors, seems however to have no prognostic significance. Conclusions This BRENDA sub-group analysis, on a German cohort of breast cancer patients confirmed the negative outcome of IBC and the different clinical behavior of IBC subtypes. The best management of IBC requires intensive coordination and cooperation between various clinical disciplines involved in the treatment of IBC patients. Moreover there is a need to identify IBC-specific targeted therapies to improve the curing prospects of this subtype of cancer.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-015-3691-4