The basal forebrain cholinergic system and object memory in the rat

Rats with near complete destruction of basal forebrain cholinergic neurons from intracerebroventricular injections of 192 IgG-saporin were trained on object discrimination problems and then retrained two weeks later to measure retention. Despite dramatic reductions of acetylcholinesterase-positive f...

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Bibliographic Details
Published in:Brain research 1996-02, Vol.710 (1), p.265-270
Main Authors: Vnek, Norbert, Kromer, Lawrence F., Wiley, Ronald G., Rothblat, Lawrence A.
Format: Article
Language:English
Subjects:
192 IgG-saporin
Acetylcholinesterase - metabolism
Animals
Antibodies, Monoclonal - pharmacology
Behavioral psychophysiology
Biological and medical sciences
Cerebral Cortex - enzymology
Cholinergic Agents - pharmacology
Cholinergic hypothesis
Fundamental and applied biological sciences. Psychology
Hippocampus
Hippocampus - enzymology
Immunotoxin
Immunotoxins - pharmacology
Injections, Intraventricular
Male
Memory - drug effects
Memory - physiology
N-Glycosyl Hydrolases
Ncocortex
Neurons - drug effects
Neurotransmission and behavior
Non-spatial memory
Parasympathetic Nervous System - cytology
Parasympathetic Nervous System - drug effects
Parasympathetic Nervous System - physiology
Prosencephalon - cytology
Prosencephalon - drug effects
Prosencephalon - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Wistar
Retention (Psychology) - drug effects
Retention (Psychology) - physiology
Ribosome Inactivating Proteins, Type 1
Saporins
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Summary:Rats with near complete destruction of basal forebrain cholinergic neurons from intracerebroventricular injections of 192 IgG-saporin were trained on object discrimination problems and then retrained two weeks later to measure retention. Despite dramatic reductions of acetylcholinesterase-positive fibers in hippocampus and neocortex, these animals did not differ from controls on an analysis of savings scores. Thus, the basal forebrain cholinergic system may serve functions that support non-spatial memory but are not specifically mnemonic in nature.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(95)01477-2