Voltage-dependent K super(+) currents contribute to heterogeneity of olfactory ensheathing cells

The olfactory nerve is permissive for axon growth throughout life. This has been attributed in part to the olfactory ensheathing glial cells that encompass the olfactory sensory neuron fascicles. Olfactory ensheathing cells (OECs) also promote axon growth in vitro and when transplanted in vivo to si...

Full description

Saved in:
Bibliographic Details
Published in:Glia 2015-09, Vol.63 (9), p.1646-1659
Main Authors: Rela, Lorena, Piantanida, Ana Paula, Bordey, Angelique, Greer, Charles A
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The olfactory nerve is permissive for axon growth throughout life. This has been attributed in part to the olfactory ensheathing glial cells that encompass the olfactory sensory neuron fascicles. Olfactory ensheathing cells (OECs) also promote axon growth in vitro and when transplanted in vivo to sites of injury. The mechanisms involved remain largely unidentified owing in part to the limited knowledge of the physiological properties of ensheathing cells. Glial cells rely for many functions on the properties of the potassium channels expressed; however, those expressed in ensheathing cells are unknown. Here we show that OECs express voltage-dependent potassium currents compatible with inward rectifier (K sub(ir)) and delayed rectifier (K sub(DR)) channels. Together with gap junction coupling, these contribute to the heterogeneity of membrane properties observed in OECs. The relevance of K super(+) currents expressed by ensheathing cells is discussed in relation to plasticity of the olfactory nerve. GLIA 2015; 63:1646-1659 Main Points * This is the first characterization of olfactory ensheathing glia potassium currents, showing variable expression of inward and delayed rectifier potassium channels, and gap junction channels. * Diversity relates in part to location of cells in different layers of the olfactory bulb.
ISSN:0894-1491
1098-1136
DOI:10.1002/glia.22834