MiR-92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN-Mediated PI3K/AKT Pathway

Background MicroRNAs regulate gene expression at the posttranscriptional level and play important roles in tumor development, progression, and metastasis. The aim of this study was to investigate the role of microRNA-92a ( miR-92a ) in metastasis of colorectal cancer (CRC). Methods One hundred fifty...

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Bibliographic Details
Published in:Annals of surgical oncology 2015-08, Vol.22 (8), p.2649-2655
Main Authors: Ke, Tao-Wei, Wei, Po-Li, Yeh, Ken-Tu, Chen, William Tzu-Liang, Cheng, Ya-Wen
Format: Article
Language:English
Subjects:
Aged
Cadherins - genetics
Cadherins - metabolism
Cell Line, Tumor
Cell Movement - genetics
Colorectal Cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Disease-Free Survival
Female
Gene Expression
Gene Knockdown Techniques
Humans
Lymphatic Metastasis
Male
Medicine
Medicine & Public Health
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
Oncology
Phosphatidylinositol 3-Kinases - metabolism
Proto-Oncogene Proteins c-akt - metabolism
PTEN Phosphohydrolase - genetics
PTEN Phosphohydrolase - metabolism
Signal Transduction
Surgery
Surgical Oncology
Survival Rate
Up-Regulation
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Summary:Background MicroRNAs regulate gene expression at the posttranscriptional level and play important roles in tumor development, progression, and metastasis. The aim of this study was to investigate the role of microRNA-92a ( miR-92a ) in metastasis of colorectal cancer (CRC). Methods One hundred fifty-eight CRC patients were enrolled. The expression of miR - 92a, PTEN, and E - cadherin was analyzed by real-time PCR. Univariate (Kaplan–Meier) analysis was used to analyze primary outcomes included 5-year overall survival and tumor recurrence. CRC cell model studies were used to analyze the miR-92a -involved CRC metastasis. Results The expression of miR - 92a in tumor tissues was significantly positively correlated with lymph node metastasis in CRC patients ( p  = 0.012). After adjusting for age, sex, and disease differentiation, this correlation remained significant ( p  = 0.01). In addition, there was a negative correlation between levels of miR-92a and the PTEN gene ( p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-014-4305-2