Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat, a spontaneous type 2 diabetic animal model

The Goto-Kakizaki (GK) rat is a spontaneous type 2 diabetic animal model, which is characterized by a progressive loss of beta islet cells with fibrosis. In the present study, the hypoglycemic effect of asiatic acid (AA) in GK rats was examined. GK rats receiving AA at a daily dose of 25 mg·kg−1 for...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2015-07, Vol.13 (7), p.529-534
Main Authors: WANG, Xue, LU, Qian, YU, Dong-Sheng, CHEN, Yu-Peng, SHANG, Jing, ZHANG, Lu-Yong, SUN, Hong-Bin, LIU, Jun
Format: Article
Language:English
Subjects:
Animals
Asiatic acid
Blood Glucose - metabolism
Centella - chemistry
Diabetes mellitus
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - pathology
Disease Models, Animal
Fibronectins - metabolism
Fibrosis
Glucose Tolerance Test
Goto-Kakizaki (GK) rats
Hyperglycemia
Hyperglycemia - drug therapy
Hyperglycemia - pathology
Insulin - blood
Insulin Resistance
Islet fibrosis
Islets of Langerhans - drug effects
Islets of Langerhans - pathology
Male
Pancreas
Pancreatic Diseases - metabolism
Pancreatic Diseases - pathology
Pancreatic Diseases - prevention & control
Pentacyclic Triterpenes - pharmacology
Pentacyclic Triterpenes - therapeutic use
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rats, Inbred Strains
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Summary:The Goto-Kakizaki (GK) rat is a spontaneous type 2 diabetic animal model, which is characterized by a progressive loss of beta islet cells with fibrosis. In the present study, the hypoglycemic effect of asiatic acid (AA) in GK rats was examined. GK rats receiving AA at a daily dose of 25 mg·kg−1 for four weeks showed a significant reduction in blood glucose levels. Age-matched normal Wistar rats were given 0.5% sodium carboxymethyl cellulose (CMC-Na) solution for the same periods and used as control. Compared to the normal Wistar rats, GK rats treated with AA showed improvement in insulin resistance partially through decreasing glucose level (P < 0.01) and insulin level (P < 0.05). Furthermore, the results of immunohistochemistry indicate that AA treatment reduced islet fibrosis in GK rats. Fibronectin, a key protein related to islet fibrosis, was over-expressed in GK rats, which was reversed significantly by AA treatment (P < 0.05). These findings suggest that AA has a beneficial effect on lowering blood glucose levels in GK rats and improves fibrosis of islets in diabetes, which may play a role in the prevention of islets dysfunction
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(15)30047-9