Biology and immunology of cancer stem(-like) cells in head and neck cancer

Highlights • Cancer stem(-like) cells (CSCs) represent a subpopulation of head and neck cancer. • CSCs contribute to resistance to current therapies. • The immune system can recognize CSCs. • In turn CSC may evade the hosts’ immune response and induce immune suppression. • Ways of improving immune r...

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Bibliographic Details
Published in:Critical reviews in oncology/hematology 2015-09, Vol.95 (3), p.337-345
Main Authors: Qian, Xu, Ma, Chenming, Nie, Xiaobo, Lu, Jianxin, Lenarz, Minoo, Kaufmann, Andreas M, Albers, Andreas E
Format: Article
Language:English
Subjects:
ALDH1
Cancer stem cells
Carcinoma, Squamous Cell - immunology
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Carcinoma, Squamous Cell - virology
Epithelial–mesenchymal transition
Head and Neck Neoplasms - immunology
Head and Neck Neoplasms - pathology
Head and Neck Neoplasms - therapy
Head and Neck Neoplasms - virology
Hematology, Oncology and Palliative Medicine
Human papillomavirus
Humans
Immune Tolerance
Immunotherapy
Neoplasm Metastasis
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - immunology
Neoplastic Stem Cells - pathology
Neoplastic Stem Cells - radiation effects
Squamous Cell Carcinoma of Head and Neck
Tumor Escape
Vaccination
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Summary:Highlights • Cancer stem(-like) cells (CSCs) represent a subpopulation of head and neck cancer. • CSCs contribute to resistance to current therapies. • The immune system can recognize CSCs. • In turn CSC may evade the hosts’ immune response and induce immune suppression. • Ways of improving immune responses to CSC are explored for immunotherapy.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2015.03.009