The Molecular Machinery of Neurotransmitter Release (Nobel Lecture)

The most important property of synaptic transmission is its speed, which is crucial for the overall workings of the brain. In his Nobel Lecture, T. C. Südhof explains how the synaptic vesicle and the plasma membrane undergo rapid fusion during neurotransmitter release and how this process is spatial...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2014-11, Vol.53 (47), p.12696-12717
Main Author: Sudhof, Thomas C
Format: Article
Language:English
Subjects:
Brain
Calcium - metabolism
hormone secretion
Humans
intracellular signaling
Lectures
Membrane Fusion
Membranes
Molecular machinery
Neuronal Plasticity
Neurotransmitter Agents - metabolism
Neurotransmitter Agents - secretion
Neurotransmitters
Nobel Prize
Signal processing
SNARE Proteins - metabolism
synaptic plasticity
Synaptotagmins - metabolism
Translations
Vesicles
vesicular transport
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Summary:The most important property of synaptic transmission is its speed, which is crucial for the overall workings of the brain. In his Nobel Lecture, T. C. Südhof explains how the synaptic vesicle and the plasma membrane undergo rapid fusion during neurotransmitter release and how this process is spatially organized, such that opening of Ca2+‐channels allows rapid translation of the entering Ca2+ signal into a fusion event.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201406359