Synthesis of Paclitaxel-Conjugated [beta]-Cyclodextrin Polyrotaxane and Its Antitumor Activity

Cap it all: A [beta]-cyclodextrin polyrotaxane was synthesized by using poly(propylene glycol) as the axle and [beta]-cyclodextrin as the end cap. An antitumor agent, paclitaxel, was conjugated to it. The drug-conjugated polyrotaxane penetrates deep into tumors, impedes tumor growth, and prolongs th...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-07, Vol.52 (28), p.7272-7277
Main Authors: Yu, Shuling, Zhang, Yajun, Wang, Xin, Zhen, Xu, Zhang, Zhaoheng, Wu, Wei, Jiang, Xiqun
Format: Article
Language:English
Subjects:
Axles
Glycols
Mice
Synthesis
Taxol
Tumors
Online Access:Get full text
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Summary:Cap it all: A [beta]-cyclodextrin polyrotaxane was synthesized by using poly(propylene glycol) as the axle and [beta]-cyclodextrin as the end cap. An antitumor agent, paclitaxel, was conjugated to it. The drug-conjugated polyrotaxane penetrates deep into tumors, impedes tumor growth, and prolongs the life of tumor-bearing mice better than Taxol.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201301397