Single particle ICP-MS combined with a data evaluation tool as a routine technique for the analysis of nanoparticles in complex matrices

Detection and characterization of nanoparticles (NPs) in complex media as consumer products, food and toxicological test media is an essential part of understanding the potential benefits and risks of the application of nanoparticles. Single particle ICP-MS (spICP-MS) was studied as a screening tool...

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Bibliographic Details
Published in:Journal of analytical atomic spectrometry 2015-01, Vol.3 (6), p.1274-1285
Main Authors: Peters, Ruud, Herrera-Rivera, Zahira, Undas, Anna, van der Lee, Martijn, Marvin, Hans, Bouwmeester, Hans, Weigel, Stefan
Format: Article
Language:English
Subjects:
Biological
Consumption
Foods
Gold
Mathematical analysis
Nanoparticles
Particle size
Titanium dioxide
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Summary:Detection and characterization of nanoparticles (NPs) in complex media as consumer products, food and toxicological test media is an essential part of understanding the potential benefits and risks of the application of nanoparticles. Single particle ICP-MS (spICP-MS) was studied as a screening tool for the detection and characterization of nanoparticles in complex matrices such as food and biological tissues. A data evaluation tool was created for the calculation of particle size, concentration and size distribution from the raw data. spICP-MS measurements were carried out on a standard quadrupole instrument as well as on a sector-field instrument. Performance characteristics were determined for four types of NPs. For the quadrupole instrument the size detection limits were 20 nm (Au and Ag), 50 (TiO 2 ) and 200 nm (SiO 2 ). For the sector-field instrument size detection limits are lower, 10 nm (Au). Concentration detection limits ranged from 1 ng L −1 for 60 nm Au NPs to 0.1 μg L −1 for 500 nm SiO 2 particles. The dynamic range of spICP-MS is limited to two orders of magnitude and as a consequence sample dilution is often required. The precision of the method was found to be
ISSN:0267-9477
1364-5544
DOI:10.1039/c4ja00357h