Palladium-Catalyzed Hydrocarboxylation of Alkynes with Formic Acid

A palladium‐catalyzed hydrocarboxylation of alkynes with formic acid has been developed. The method provides acrylic acid and derivatives in good yields with high regioselectivity without the need to handle toxic CO gas. Nontoxic: Acrylic acids are an important chemical feedstock. The title reaction...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2015-05, Vol.54 (21), p.6302-6305
Main Authors: Hou, Jing, Xie, Jian-Hua, Zhou, Qi-Lin
Format: Article
Language:English
Subjects:
Acrylic acid
Alkynes
Carbon monoxide
carboxylic acids
Derivatives
Feedstock
Formic acid
Handles
palladium
P ligands
synthetic methods
Toxic
Toxicology
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Summary:A palladium‐catalyzed hydrocarboxylation of alkynes with formic acid has been developed. The method provides acrylic acid and derivatives in good yields with high regioselectivity without the need to handle toxic CO gas. Nontoxic: Acrylic acids are an important chemical feedstock. The title reaction provides acrylic acid and derivatives in good yields with high regioselectivities without the need to handle toxic CO gas.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201501054