Ridge regeneration of damaged extraction sockets using rhBMP-2: an experimental study in canine

Objectives This study evaluated the dimensional ridge alteration in a buccal‐bone‐deficient extraction socket, and ridge regeneration following socket grafting accompanied by recombinant human bone morphogenetic protein 2 (rhBMP‐2) or a collagen membrane covering. Material and Methods In five beagle...

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Bibliographic Details
Published in:Journal of clinical periodontology 2015-07, Vol.42 (7), p.678-687
Main Authors: Lee, Jung-Seok, Jung, Jae-Suk, Im, Gun-Il, Kim, Byung-Soo, Cho, Kyoo-Sung, Kim, Chang-Sung
Format: Article
Language:English
Subjects:
Alveolar Bone Loss - drug therapy
Alveolar Bone Loss - surgery
alveolar ridge augmentation
Alveolar Ridge Augmentation - methods
Animals
bone morphogenetic protein 2
Bone Morphogenetic Protein 2 - therapeutic use
Bone Regeneration - drug effects
Bone Regeneration - physiology
Bone Substitutes - therapeutic use
Cattle
Collagen
Dentistry
Dogs
guided bone regeneration
Humans
Male
Mandible - drug effects
Mandible - pathology
Mandible - surgery
Membranes, Artificial
Minerals - therapeutic use
ooth extraction
Osteogenesis - drug effects
Osteogenesis - physiology
Proteins
Random Allocation
Recombinant Proteins - therapeutic use
ridge preservation
Tooth Extraction - adverse effects
Tooth Socket - drug effects
Tooth Socket - pathology
Tooth Socket - surgery
Transforming Growth Factor beta - therapeutic use
X-Ray Microtomography - methods
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Summary:Objectives This study evaluated the dimensional ridge alteration in a buccal‐bone‐deficient extraction socket, and ridge regeneration following socket grafting accompanied by recombinant human bone morphogenetic protein 2 (rhBMP‐2) or a collagen membrane covering. Material and Methods In five beagle dogs, entire buccal bone of the extracted sockets of premolars was surgically removed and immediately grafted using one of the following graft protocols: (1) sham surgery without any grafting, and grafting with (2) deproteinized bovine bone mineral (DBBM), (3) DBBM/rhBMP‐2 and (4) DBBM covered with a collagen membrane (DBBM/Membrane). Quantitative/qualitative analyses were performed radiographically/histologically after 8 weeks. Results Buccal‐deficient extraction sockets healed with significant reduction in buccolingual dimension along the entire length of the socket, but all grafting techniques reduced the dimensional changes compared to the non‐grafted control sites. Histologically, sites received DBBM only exhibited minimal regeneration, whereas sites grafted with DBBM/rhBMP‐2 or DBBM/Membrane exhibited greater new bone formation extending the entire augmented area. Conclusions Buccal‐bone‐deficiency may lead to significant volume reduction after tooth extraction along the entire length of the socket, and socket grafting accompanied by rhBMP‐2 or covered with a membrane can be candidate therapies for preservation of the buccolingual dimension and successful ridge regeneration.
ISSN:0303-6979
1600-051X
DOI:10.1111/jcpe.12414