Sodium valproate effect on the structure of rat glandule thymus: Gender-related differences

Sodium valproate (VPA) was shown to inhibit cell growth mechanisms such as cell cycle arrest, proliferation suppression, increase of apoptosis. Many aspects of the contribution of the VPA pharmacological mechanisms and their significance in gender-related processes have not been investigated. In our...

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Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2015-07, Vol.67 (7-8), p.399-406
Main Authors: Valančiūtė, Angelija, Mozuraitė, Raminta, Balnytė, Ingrida, Didžiapetrienė, Janina, Matusevičius, Paulius, Stakišaitis, Donatas
Format: Article
Language:English
Subjects:
Animals
Cell Proliferation - drug effects
Female
GABA Agents - toxicity
Gender differences
Hassall's corpuscles
Immunohistochemistry
Male
Orchiectomy
Organ Size - drug effects
Ovariectomy
Rats
Rats, Wistar
Sex Characteristics
Sodium valproate
Thymus
Thymus Gland - drug effects
Valproic Acid - toxicity
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Summary:Sodium valproate (VPA) was shown to inhibit cell growth mechanisms such as cell cycle arrest, proliferation suppression, increase of apoptosis. Many aspects of the contribution of the VPA pharmacological mechanisms and their significance in gender-related processes have not been investigated. In our study, we have tested hypothesis that the influence of VPA on thymus weight and structure might be gender-related. The thymus of Wistar rats of both genders aged 8 weeks was investigated in the following groups (n=6 each): controls, treated with VPA, castrated male and female treated with VPA, and the castrated control of both genders. The thymus weight, structural changes and area of cortical and medullar parts of the gland in slides stained with hematoxylin and eosin and immunohistochemically were assessed. A comparison of thymus weight of castrated male and of castrated VPA-treated male rats showed a significant thymus weight loss after VPA treatment (0.66±0.04g vs. 0.43±0.03g, p
ISSN:0940-2993
1618-1433
DOI:10.1016/j.etp.2015.04.005