Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing

Highlights • A single LPS stimulus results in a prolonged blunted microglia immune response. • Tolerant microglia are epigenetically silenced in vitro and in vivo. • NF-κB subunit RelB is required for epigenetic silencing of microglia. • Tolerant microglia display increased phagocytic activity....

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Published in:	Brain, behavior, and immunity behavior, and immunity, 2015-08, Vol.48, p.205-221
Main Authors:	Schaafsma, W, Zhang, X, van Zomeren, K.C, Jacobs, S, Georgieva, P.B, Wolf, S.A, Kettenmann, H, Janova, H, Saiepour, N, Hanisch, U.-K, Meerlo, P, van den Elsen, P.J, Brouwer, N, Boddeke, H.W.G.M, Eggen, B.J.L
Format:	Article
Language:	eng
Subjects:	Allergy and Immunology Animals Endotoxin tolerance Epigenesis, Genetic Epigenetic silencing Gene Silencing Histones - metabolism Innate immunity Interleukin-1beta - genetics Interleukin-1beta - metabolism Lipopolysaccharides - pharmacology Mice Microglia Microglia - drug effects Microglia - metabolism NF-kappa B - genetics NF-kappa B - metabolism Promoter Regions, Genetic Psychiatry Transcription Factor RelB - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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