Through the looking glass: Basics and principles of reflectance confocal microscopy

Reflectance confocal microscopy (RCM) offers high-resolution, noninvasive skin imaging and can help avoid obtaining unnecessary biopsy specimens. It can also increase efficiency in the surgical setting by helping to delineate tumor margins. Diagnostic criteria and several RCM algorithms have been pu...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2015-08, Vol.73 (2), p.276-284
Main Authors: Que, Syril Keena T., MD, Fraga-Braghiroli, Naiara, MD, Grant-Kels, Jane M., MD, Rabinovitz, Harold S., MD, Oliviero, Margaret, ARNP, MSN, Scope, Alon, MD
Format: Article
Language:English
Subjects:
basal cell carcinoma
Carcinoma, Basal Cell - diagnosis
Carcinoma, Basal Cell - pathology
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - pathology
cutaneous oncology
Dermatology
Diagnosis, Differential
Female
Humans
Male
melanoma
Melanoma - diagnosis
Melanoma - pathology
Microscopy, Confocal - methods
noninvasive imaging
reflectance confocal microscopy
Sensitivity and Specificity
Skin Neoplasms - diagnosis
Skin Neoplasms - pathology
squamous cell carcinoma
tumors/neoplasm
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Summary:Reflectance confocal microscopy (RCM) offers high-resolution, noninvasive skin imaging and can help avoid obtaining unnecessary biopsy specimens. It can also increase efficiency in the surgical setting by helping to delineate tumor margins. Diagnostic criteria and several RCM algorithms have been published for the differentiation of benign and malignant neoplasms. We provide an overview of the basic principles of RCM, characteristic RCM features of normal skin and cutaneous neoplasms, and the limitations and future directions of RCM.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2015.04.047