Smoking is a predictor of adverse pathological features at radical prostatectomy: Results from the Shared Equal Access Regional Cancer Hospital database

Objective To test the relationship of smoking and aggressive prostate cancer in men undergoing radical prostatectomy. Methods A retrospective analysis of 2290 men who underwent radical prostatectomy from the Shared Equal Access Regional Cancer Hospital database from 2000 to 2013 was carried out. The...

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Bibliographic Details
Published in:International journal of urology 2015-07, Vol.22 (7), p.658-662
Main Authors: Zapata, Daniel F, Howard, Lauren E, Aronson, William J, Kane, Christopher J, Terris, Martha K, Amling, Christopher L, Cooperberg, Matthew R, Freedland, Stephen J
Format: Article
Language:English
Subjects:
Aged
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
pathology
Prognosis
Prostate - pathology
Prostate - surgery
Prostate-Specific Antigen - analysis
prostatectomy
Prostatectomy - methods
prostatic neoplasms
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Retrospective Studies
risk
Risk Factors
Seminal Vesicles - pathology
smoking
Smoking - adverse effects
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Summary:Objective To test the relationship of smoking and aggressive prostate cancer in men undergoing radical prostatectomy. Methods A retrospective analysis of 2290 men who underwent radical prostatectomy from the Shared Equal Access Regional Cancer Hospital database from 2000 to 2013 was carried out. There were 1592 (70%) non‐smokers and 698 (30%) smokers at radical prostatectomy. Logistic regression was used to examine whether smoking predicted Gleason score (≥4 + 3), margin status, extracapsular extension or seminal vesicle invasion. Linear regression was used to test the relationship between smoking and tumor volume. Results Smokers were younger, more likely to be black, had lower body mass index, higher pathological Gleason score, more positive margins and extracapsular extension (all P 
ISSN:0919-8172
1442-2042
DOI:10.1111/iju.12773