FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis

FBXW7 gene (F-box and WD-40 domain protein 7) is also named HCDC4 and is a significant tumor suppressor gene, which can regulate human cell cycle, proliferation and differentiation. In this study, we tend to investigate protein expression and related biological functions of FBXW7 gene. FBXW7 express...

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Published in:Medical oncology (Northwood, London, England) London, England), 2015-08, Vol.32 (8), p.215-215, Article 215
Main Authors: Fu, Yu, Lin, Youcheng, Yang, Zhao, Yang, Guosheng, Li, Gaoyuan, Liu, Yuejia, Tan, Xi, Huang, Yi, Wu, Xun, Wang, Yongqiang, Xiong, Hu, Zhang, Meng, Fang, Lu, Ge, Yukun, Zeng, Jun, Cai, Yangke, Bai, Jian, Wu, Song
Format: Article
Language:English
Subjects:
Apoptosis - genetics
Biomarkers, Tumor - genetics
Carcinoma, Renal Cell - genetics
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - pathology
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell Line, Tumor
Cell Proliferation - genetics
F-Box Proteins - genetics
F-Box Proteins - metabolism
F-Box-WD Repeat-Containing Protein 7
Female
Gene Expression Regulation, Neoplastic
Hematology
Humans
Internal Medicine
Kidney Neoplasms - genetics
Kidney Neoplasms - mortality
Kidney Neoplasms - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Paper
Pathology
Prognosis
Survival Analysis
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
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Summary:FBXW7 gene (F-box and WD-40 domain protein 7) is also named HCDC4 and is a significant tumor suppressor gene, which can regulate human cell cycle, proliferation and differentiation. In this study, we tend to investigate protein expression and related biological functions of FBXW7 gene. FBXW7 expression level in renal cell carcinoma (RCC) tissues is highly related to its clinical pathologic grade ( P  = 0.0094) and TNM phase ( P  = 0.0080) and is highly lower than in paracancerous normal tissues through immunohistochemistry study. FBXW7 high-expression patients have overall better prognosis than low-expression patients ( P  
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-015-0656-1