Squamous cell carcinoma of the rectum: The treatment paradigm

Abstract Purpose This study was planned to clarify the optimal treatment for squamous cell carcinoma of the rectum, an histological entity extremely rare. Methods Ten patients with histologically proven squamous cell carcinoma of the rectum were treated with concomitant radiochemotherapy. Radiation...

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Bibliographic Details
Published in:European journal of surgical oncology 2015-08, Vol.41 (8), p.1054-1058
Main Authors: Musio, D, De Felice, F, Manfrida, S, Balducci, M, Meldolesi, E, Gravina, G.L, Tombolini, V, Valentini, V
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - therapy
Disease-Free Survival
Female
Follow-Up Studies
Hematology, Oncology and Palliative Medicine
Humans
Italy - epidemiology
Male
Middle Aged
Prognosis
Radiochemotherapy
Radiotherapy
Rectal cancer
Rectal Neoplasms - mortality
Rectal Neoplasms - therapy
Retrospective Studies
Squamous cell carcinoma
Surgery
Survival Rate
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Summary:Abstract Purpose This study was planned to clarify the optimal treatment for squamous cell carcinoma of the rectum, an histological entity extremely rare. Methods Ten patients with histologically proven squamous cell carcinoma of the rectum were treated with concomitant radiochemotherapy. Radiation therapy was delivered with a 3Dconformational multiple field technique to a dose ranging from 45 to 76.5 Gy, with 6–15 MV energy photons. Chemotherapy consisted of an antimetabolite drug in association with mitomycin C or oxaliplatin. Overall survival and disease free survival were considered in months from the end of the concomitant treatment. Results All patients completed programmed radiochemotherapy treatment but two patients were excluded to the analysis. Six patients (75%) presented negative biopsy 6 months after the end of radiochemotherapy. Seven patients (87.5%) showed a tumour regression after initial treatment. Only 1 patient underwent salvage surgery. Considering a mean follow-up of 41.75 months, 7 patients are still disease free survivors. Only 1 patient developed local recurrence at 6 months and he died 14 months after abdomino-perineal resection. Conclusion Primary radio chemotherapy, with a curative intent, could be considered the treatment modality of choice for squamous carcinoma of the rectum.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2015.03.239