Cellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways

Abstract The interconnectivity between diet, gut microbiota and cell molecular responses is well known; however, only recently has technology allowed the identification of strains of microorganisms harbored in the gastrointestinal tract that may increase susceptibility to cancer. The colonic environ...

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Bibliographic Details
Published in:Cancer letters 2015-01, Vol.356 (2), p.273-280
Main Authors: Hagland, Hanne R, Søreide, Kjetil
Format: Article
Language:English
Subjects:
Body Mass Index
Butyrate
Carcinogenesis - metabolism
Colorectal cancer
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - microbiology
Colorectal Neoplasms - pathology
Diet
Energy metabolism
Fatty acids
Gastrointestinal Tract - microbiology
Gastrointestinal Tract - pathology
Glycolysis - physiology
Hematology, Oncology and Palliative Medicine
Humans
Life Style
Lipids
Metabolic Networks and Pathways
Microbiota
Mitochondria
Obesity - complications
Oxidative Phosphorylation
Risk Factors
Studies
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Summary:Abstract The interconnectivity between diet, gut microbiota and cell molecular responses is well known; however, only recently has technology allowed the identification of strains of microorganisms harbored in the gastrointestinal tract that may increase susceptibility to cancer. The colonic environment appears to play a role in the development of colon cancer, which is influenced by the human metabolic lifestyle and changes in the gut microbiome. Studying metabolic changes at the cellular level in cancer be useful for developing novel improved preventative measures, such as screening through metabolic breath-tests or treatment options that directly affect the metabolic pathways responsible for the carcinogenicity.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.02.026