Renal denervation restores the baroreflex control of renal sympathetic nerve activity and heart rate in Wistar-Kyoto rats with cisplatin-induced renal failure

Aim There is evidence that in chronic renal failure, the sympathetic nervous system is activated. This study investigated the role of the renal innervation in suppressing high‐ and low‐pressure baroreflex control of renal sympathetic nerve activity and heart rate in cisplatin‐induced renal failure....

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Bibliographic Details
Published in:Acta Physiologica 2014-03, Vol.210 (3), p.690-700
Main Authors: Khan, S. A., Sattar, M. A., Rathore, H. A., Abdulla, M. H., ud din Ahmad, F., Ahmad, A., Afzal, S., Abdullah, N. A., Johns, E. J.
Format: Article
Language:English
Subjects:
Animals
baroreceptor reflexes
Baroreflex - physiology
Cisplatin - toxicity
cisplatin-induced renal failure
Cross-Linking Reagents - toxicity
Disease Models, Animal
Heart Rate - physiology
Kidney - innervation
Kidney - physiology
Male
Rats
Rats, Inbred WKY
renal denervation
Renal Insufficiency - chemically induced
Renal Insufficiency - physiopathology
renal sympathetic nerve activity
Sympathectomy
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Summary:Aim There is evidence that in chronic renal failure, the sympathetic nervous system is activated. This study investigated the role of the renal innervation in suppressing high‐ and low‐pressure baroreflex control of renal sympathetic nerve activity and heart rate in cisplatin‐induced renal failure. Methods Renal failure was induced using cisplatin (5 mg kg−1, i.p.) and the rats used 7 days later. Groups of rats were anaesthetized and prepared for measurement of renal sympathetic nerve activity and heart rate. Acute unilateral or bilateral renal denervation was performed, and renal sympathetic nerve activity and heart rate baroreflex gain curves were generated while the cardiopulmonary receptors were stimulated using an acute saline volume load. Results Cisplatin administration reduced (P 
ISSN:1748-1708
1748-1716
DOI:10.1111/apha.12237