Evaluation of right ventricular function in fetuses with hypoplastic left heart syndrome using tissue Doppler techniques

ABSTRACT Objective The outcome of patients with hypoplastic left heart syndrome (HLHS) is influenced by right ventricular function. This study aimed to investigate whether differences in right ventricular function of fetuses with HLHS are present during gestation. Methods This was a prospective stud...

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Published in:Ultrasound in obstetrics & gynecology 2015-06, Vol.45 (6), p.670-677
Main Authors: Axt‐Fliedner, R., Graupner, O., Kawecki, A., Degenhardt, J., Herrmann, J., Tenzer, A., Doelle, A., Willruth, A., Steinhard, J., Gembruch, U., Bahlmann, F., Enzensberger, C.
Format: Article
Language:English
Subjects:
Blood Flow Velocity
cardiac function
Case-Control Studies
Echocardiography, Doppler - methods
Female
Fetal Heart - diagnostic imaging
Fetal Heart - physiopathology
fetus
Gestational Age
Humans
hypoplastic left heart
Hypoplastic Left Heart Syndrome - diagnostic imaging
Hypoplastic Left Heart Syndrome - physiopathology
Pregnancy
Prospective Studies
TDI
tissue Doppler imaging
Ultrasonography, Prenatal - methods
Ventricular Function, Right
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Summary:ABSTRACT Objective The outcome of patients with hypoplastic left heart syndrome (HLHS) is influenced by right ventricular function. This study aimed to investigate whether differences in right ventricular function of fetuses with HLHS are present during gestation. Methods This was a prospective study comprising 14 fetuses with HLHS (28 measurements obtained in total) and 28 normal control fetuses (31 measurements obtained in total). The two groups were matched for gestational age. Ultrasound M‐mode was used to assess displacement of the tricuspid annulus. Spectral Doppler and myocardial tissue Doppler‐derived inflow and outflow velocities were assessed. Tricuspid valve peak early wave to peak active wave (E/A) ratio, the early wave to early diastolic annular relaxation velocity (E/E′) ratio and the tissue Doppler‐derived myocardial performance index (MPI′) were calculated. Results E‐wave velocity was significantly higher in fetuses with HLHS than in control fetuses (mean, 40.14 cm/s vs 35.47 cm/s; P 
ISSN:0960-7692
1469-0705
DOI:10.1002/uog.14736