Primary multifocal lymphoma of peripheral nervous system: Case report and review of the literature

ABSTRACT Introduction: Primary lymphomas of peripheral nerves are extremely rare, and only a few cases have been reported. Methods: We describe the clinical, neurophysiological, radiological, and pathological findings in a 61‐year‐old woman affected by primary multifocal lymphoma of the peripheral n...

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Published in:Muscle & nerve 2014-12, Vol.50 (6), p.1016-1022
Main Authors: Del Grande, Alessandra, Sabatelli, Mario, Luigetti, Marco, Conte, Amelia, Granata, Giuseppe, Rufini, Vittoria, Del Ciello, Annemilia, Gaudino, Simona, Fernandez, Eduardo, Hohaus, Stefan, Coli, Antonella, Lauriola, Libero
Format: Article
Language:English
Subjects:
Biopsy
FDG PET‐CT
Female
Femoral Nerve - pathology
Humans
Lymphoma
Lymphoma, Non-Hodgkin - diagnosis
Lymphoma, Non-Hodgkin - diagnostic imaging
Lymphoma, Non-Hodgkin - pathology
Magnetic Resonance Imaging
Medical research
Middle Aged
Neoplasms, Multiple Primary - diagnosis
Neoplasms, Multiple Primary - diagnostic imaging
Neoplasms, Multiple Primary - pathology
nerve biopsy
nerve ultrasound
Nervous system
neurolymphomatosis
Peripheral Nervous System Neoplasms - diagnosis
Peripheral Nervous System Neoplasms - diagnostic imaging
Peripheral Nervous System Neoplasms - pathology
Positron-Emission Tomography
primary lymphoma of peripheral nerves
Tomography
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Summary:ABSTRACT Introduction: Primary lymphomas of peripheral nerves are extremely rare, and only a few cases have been reported. Methods: We describe the clinical, neurophysiological, radiological, and pathological findings in a 61‐year‐old woman affected by primary multifocal lymphoma of the peripheral nervous system without systemic involvement. Results: Fascicular left femoral nerve biopsy was decisive for the diagnosis of diffuse large B‐cell non‐Hodgkin lymphoma. Magnetic resonance imaging, fluorine‐18 fluorodeoxyglucose positron emission tomography computed tomography, and nerve ultrasound contributed to the diagnosis. Conclusions: Primary lymphoma of peripheral nerves (PLPNs) is a rare but potentially treatable condition, which is frequently misdiagnosed. In the literature, there are very few descriptions of PLPNs, most of which are mononeuropathies. The possibility of a neuropathy associated with lymphoma should be considered in patients with poor response to treatment and severe pain symptoms. Muscle Nerve 50: 1016–1022, 2014
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.24354