Childhood allergic asthma is associated with increased IL-13 and FOXP3 histone acetylation

Epigenetic mechanisms including DNA methylation and histone acetylation play a major role in controlling the polarization of naive T cells toward different effector T cells such as TH1, TH2, and regulatory T (Treg) cells and may thus modify the risk for disease development by modulating the developm...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2015-07, Vol.136 (1), p.200-202
Main Authors: Harb, Hani, MSc, Raedler, Diana, PhD, Ballenberger, Nikolaus, PhD, Böck, Andreas, PhD, Kesper, Dörthe A., PhD, Renz, Harald, MD, Schaub, Bianca, MD
Format: Article
Language:English
Subjects:
Acetylation
Adolescent
Allergy and Immunology
Asthma - immunology
Chromatin
DNA methylation
Epigenesis, Genetic - immunology
Female
Forkhead Transcription Factors - genetics
Forkhead Transcription Factors - metabolism
Gene loci
Histones - metabolism
Humans
Hypersensitivity - immunology
Interleukin-13 - genetics
Interleukin-13 - metabolism
Male
Studies
T-Lymphocyte Subsets - immunology
Th1-Th2 Balance
Th2 Cells - immunology
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Summary:Epigenetic mechanisms including DNA methylation and histone acetylation play a major role in controlling the polarization of naive T cells toward different effector T cells such as TH1, TH2, and regulatory T (Treg) cells and may thus modify the risk for disease development by modulating the developmental function of these T-cell populations.1 Recently, the link between epigenetic modifications and the risk for asthma development was investigated in several cohort studies, which mainly focused on DNA methylation,2 whereas little is known about the role of histone modifications including histone acetylation during asthma manifestation. Histone acetylation as an epigenetic marker for transcriptional activation was measured in a subgroup of 4- to 15-year-old steroid-naive children with AA and HC children from the Munich Clinical Asthma Research Association (CLARA) study population (n(AA) = 14, n(HCs) = 18).3 Children with AA were characterized by increased eosinophils, IgE, and fractional exhaled nitric oxide compared with HC children and showed a significant bronchodilator response4 according to American Thoracic Society/European Respiratory Society guidelines.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.01.027