Antibacterial, cytotoxicity and physical properties of laser — Silver doped hydroxyapatite layers

Hydroxyapatite layers with silver doping from 0.06at.% to 14at.% were prepared by laser deposition. The films' physical properties such as morphology, composition, crystallinity, Young's modulus and microhardness were measured. Films were amorphous or polycrystalline in dependence on depos...

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Bibliographic Details
Published in:Materials Science & Engineering C 2013-04, Vol.33 (3), p.1242-1246
Main Authors: Jelinek, M., Kocourek, T., Remsa, J., Weiserová, M., Jurek, K., Mikšovský, J., Strnad, J., Galandáková, A., J.Ulrichová
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antibacterial
Antibacterial properties
Bacillus subtilis
Cell Death - drug effects
Crystallinity
Crystallization
Cytotoxicity
Doping
Durapatite - pharmacology
Elastic Modulus - drug effects
Escherichia coli
Escherichia coli - drug effects
Fibroblasts - cytology
Fibroblasts - drug effects
Hardness - drug effects
Hydroxyapatite
Lasers
Mice
Microbial Sensitivity Tests
Microscopy, Electron, Scanning
NIH 3T3 Cells
Physical properties
PLD
Silicon - pharmacology
Silver
Staphylococcus aureus - drug effects
Thin films
Titanium - pharmacology
Ultrasonic testing
X-Ray Diffraction
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Description
Summary:Hydroxyapatite layers with silver doping from 0.06at.% to 14at.% were prepared by laser deposition. The films' physical properties such as morphology, composition, crystallinity, Young's modulus and microhardness were measured. Films were amorphous or polycrystalline in dependence on deposition temperature (from RT to 600°C). Antibacterial properties were tested using Escherichia coli and Bacillus subtilis cells. The antibacterial efficacy changed with silver doping from 4% to 100%. Cytotoxicity was studied by a direct contact test. Depending on doping and crystallinity the films were either non-toxic or mildly toxic. ► Silver doped hydroxyapatite layers synthetized by laser deposition ► Study of antibacterial properties (Gram positive and Gram negative bacteria) ► From cytotoxicity tests it follows that doped amorphous HA layers are mildly toxic.
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2012.12.018