Magnetic and degradable polymer/bioactive glass composite nanoparticles for biomedical applications

[Display omitted] ► Iron oxide incorporated chitosan-gelatin-bioglass nanocomposite was developed. ► The size of the negatively charged composite was in the range of 43–51nm. ► The nanocomposite is a soft magnetic material. ► The nanocomposites demonstrated minimal protein adsorption as analysed by...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2013-01, Vol.101 (1), p.196-204
Main Authors: Jayalekshmi, A.C., Victor, Sunita Prem, Sharma, Chandra P.
Format: Article
Language:English
Subjects:
Adsorption
Agglomeration
bioactive properties
Biocompatible Materials
Biodegradability
biodegradation
Bioglass
Blood compatibility
Calorimetry, Differential Scanning
Chitosan
colloids
differential scanning calorimetry
Drug Delivery Systems
drug therapy
Electrochemistry
Electrophoresis, Polyacrylamide Gel
Erythrocyte Aggregation - drug effects
Ferric Compounds - chemistry
Fourier transform infrared spectroscopy
Gelatin
Glass
hemolysis
Hemolysis - drug effects
Humans
Hyperthermia, Induced - methods
hysteresis
In Vitro Techniques
in vivo studies
Iron oxides
Magnetic
Magnetic materials
Magnetics
Microscopy, Electron, Transmission
Nanoparticles
Platelet Aggregation - drug effects
polymers
Protein adsorption
Serum Albumin - chemistry
Silicates - chemistry
Spectroscopy, Fourier Transform Infrared
Thermogravimetry
transmission electron microscopy
X-Ray Diffraction
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Summary:[Display omitted] ► Iron oxide incorporated chitosan-gelatin-bioglass nanocomposite was developed. ► The size of the negatively charged composite was in the range of 43–51nm. ► The nanocomposite is a soft magnetic material. ► The nanocomposites demonstrated minimal protein adsorption as analysed by PAGE. ► The nanocomposite could generate heat energy in an applied magnetic field. The present study focuses on the development of a biocompatible and biodegradable iron oxide incorporated chitosan-gelatin bioglass composite nanoparticles [Fe-BG]. The developed composite nanoparticle was analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, thermo gravimetric analysis (TG) and differential scanning calorimetry analysis (DSC). The size of the negatively charged composite nanoparticle was in the range of 43–51nm. The in vitro analysis of the composite nanoparticles was carried out by cell aggregation, protein adsorption and haemolytic activity. The magnetic hysteresis value of the composite nanoparticle showed that it is a soft magnetic material. The presence of iron oxide in the chitosan-gelatin bioglass [BG] matrix enhances biodegradability as indicated in the TG studies. Iron-oxide in equal amount to bioglass in the polymer matrix has been obtained as the optimized system. The developed composite nanoparticle is a soft magnetic material and is suitable for the magnetic hyperthermia treatment and drug delivery. More detailed in vivo studies are needed to confirm the biodegradation profile and biological activity of the material.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2012.06.027