Elevated insulin resistance in patients with recurrent aphthous stomatitis

Objectives The role of glucose metabolism disorders in periodontal diseases including recurrent aphthous stomatitis (RAS) is currently attracting attention. The aim of this study is to investigate insulin resistance (IR) in patients with RAS in otherwise healthy individuals. Materials and methods Th...

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Bibliographic Details
Published in:Clinical oral investigations 2015-07, Vol.19 (6), p.1193-1197
Main Authors: Takci, Z., Karadag, A. S., Ertugrul, D. T., Bilgili, S. G.
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Blood Glucose - analysis
C-Peptide - blood
Case-Control Studies
Cholesterol - blood
Dentistry
Female
Glycated Hemoglobin A - analysis
Humans
Insulin - blood
Insulin Resistance
Male
Medicine
Original Article
Recurrence
Stomatitis, Aphthous - blood
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Summary:Objectives The role of glucose metabolism disorders in periodontal diseases including recurrent aphthous stomatitis (RAS) is currently attracting attention. The aim of this study is to investigate insulin resistance (IR) in patients with RAS in otherwise healthy individuals. Materials and methods The study enrolled 81 patients with RAS and 61 healthy control subjects. Blood glucose, insulin, C-peptide, hemoglobin A1c, total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and HOMA-IR were measured in each individual. Results Forty-two of the RAS group were in the active, and 39 of the RAS group were in the passive stage. The levels of c-peptide, insulin, and HOMA-IR were remarkably higher in the RAS group ( p  = 0.015; p  
ISSN:1432-6981
1436-3771
DOI:10.1007/s00784-014-1339-6