Loss of normal anagen hair in pemphigus vulgaris

Summary Background Pemphigus vulgaris (PV) is a known cause of loss of ‘normal’ anagen hair; that is, shedding of intact anagen hairs covered by root sheaths. However, studies on this subject are limited. Aim To investigate anagen hair shedding in patients with PV, and ascertain its association with...

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Bibliographic Details
Published in:Clinical and experimental dermatology 2015-07, Vol.40 (5), p.485-488
Main Authors: Daneshpazhooh, M., Mahmoudi, H. R., Rezakhani, S., Valikhani, M., Naraghi, Z. S., Mohammadi, Y., Habibi, A., Chams-Davatchi, C.
Format: Article
Language:English
Subjects:
Adult
Aged
Alopecia - etiology
Alopecia - pathology
Female
Hair - growth & development
Humans
Male
Middle Aged
Multivariate Analysis
Pemphigus - complications
Pemphigus - pathology
Phenotype
Scalp Dermatoses - complications
Scalp Dermatoses - pathology
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Summary:Summary Background Pemphigus vulgaris (PV) is a known cause of loss of ‘normal’ anagen hair; that is, shedding of intact anagen hairs covered by root sheaths. However, studies on this subject are limited. Aim To investigate anagen hair shedding in patients with PV, and ascertain its association with disease severity. Methods In total, 96 consecutive patients with PV (new patients or patients in relapse) who were admitted to the dermatology wards of a tertiary hospital were enrolled in this study. Demographic data, PV phenotype, disease severity and presence of scalp lesions were recorded. A group of 10–20 hairs were pulled gently from different areas of the scalp (lesional and nonlesional skin) in all patients, and anagen hairs were counted. Disease severity was graded according to Harman score. Results Anagen hair was obtained by pull test in 59 of the 96 patients (61.5%), of whom 2 had normal scalp. The mean ± SD anagen hair count was 5.9 ± 7.6 (range 0–31). In univariate analysis, anagen hair loss (P 
ISSN:0307-6938
1365-2230
DOI:10.1111/ced.12595