Ru-Catalyzed Regioselective CH-Hydroarylation of Alkynes with Benzylthioethers Using Sulfur as Directing Group

Benzylthioethers react with internal alkynes in the presence of catalytic amounts of [Ru­(cymene)­Cl2]2 to give the corresponding ortho-alkenylated species, using sulfur as the sole directing group. The reaction is regiospecific, tolerates different substituents at both the sulfur and the aryl ring,...

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Bibliographic Details
Published in:Organic letters 2015-06, Vol.17 (12), p.3178-3181
Main Authors: Villuendas, Pedro, Urriolabeitia, Esteban P
Format: Article
Language:English
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Summary:Benzylthioethers react with internal alkynes in the presence of catalytic amounts of [Ru­(cymene)­Cl2]2 to give the corresponding ortho-alkenylated species, using sulfur as the sole directing group. The reaction is regiospecific, tolerates different substituents at both the sulfur and the aryl ring, and proceeds very efficiently with a large variety of electron-rich alkynes.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b01552