Changes in Echocardiographic Parameters in Iron Deficiency Patients with Heart Failure and Chronic Kidney Disease Treated with Intravenous Iron

Background Treatment of iron deficiency helps to improve cardiac and renal function in patients with chronic heart failure. However, the mechanism by which this occurs is currently unclear. Methods We undertook a double-blind, randomised, placebo-controlled study of intravenous iron sucrose treatmen...

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Bibliographic Details
Published in:Heart, lung & circulation lung & circulation, 2015-07, Vol.24 (7), p.686-695
Main Authors: Toblli, Jorge E., MD, PhD, FASN, Di Gennaro, Federico, Rivas, Carlos
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anemia, Iron-Deficiency - blood
Anemia, Iron-Deficiency - complications
Anemia, Iron-Deficiency - drug therapy
Cardiovascular
Chronic kidney disease
Double-Blind Method
Female
Ferric Compounds - administration & dosage
Ferritin
Glucaric Acid - administration & dosage
Heart failure
Heart Failure - blood
Heart Failure - complications
Heart Failure - drug therapy
Heart Failure - physiopathology
Hematinics - administration & dosage
Humans
Iron - blood
Iron - deficiency
Iron sucrose
Male
Pilot Projects
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - drug therapy
Renal Insufficiency, Chronic - physiopathology
TSAT
Ventricular Function, Left - drug effects
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Summary:Background Treatment of iron deficiency helps to improve cardiac and renal function in patients with chronic heart failure. However, the mechanism by which this occurs is currently unclear. Methods We undertook a double-blind, randomised, placebo-controlled study of intravenous iron sucrose treatment (200 mg/mL weekly for five weeks) in patients with chronic heart failure, chronic kidney disease and iron-deficiency anaemia receiving optimal treatment for chronic heart failure (N=60). Markers of disease severity, iron status, anaemia and inflammation were measured during a six-month follow-up period, and evaluation of echocardiographic parameters was performed at baseline and six months after treatment. Results At six months after treatment initiation, intravenous iron was associated with reduced severity of the symptoms of chronic heart failure and improved renal function (both p
ISSN:1443-9506
1444-2892
DOI:10.1016/j.hlc.2014.12.161