Advances in preimplantation genetic diagnosis/screening

Preimplantation genetic diagnosis（PGD） gives couples who have a high risk of transmitting genetic disorders to their baby the chance to have a healthy offspring through embryo genetic analysis and selection.Preimplantation genetic screening（PGS） is an effective method to select euploid embryos that...

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Bibliographic Details
Published in:Science China. Life sciences 2014-07, Vol.57 (7), p.665-671
Main Authors: Yan, LiYing, Wei, Yuan, Huang, Jin, Zhu, XiaoHui, Shi, XiaoDan, Xia, Xi, Yan, Jie, Lu, CuiLing, Lian, Ying, Li, Rong, Liu, Ping, Qiao, Jie
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Blastocyst - metabolism
Blastocyst - pathology
Chromosome Disorders - diagnosis
Chromosome Disorders - genetics
Comparative Genomic Hybridization
Female
High-Throughput Nucleotide Sequencing
Humans
In Situ Hybridization, Fluorescence
Life Sciences
PGS
Pregnancy
Preimplantation Diagnosis - methods
Preimplantation Diagnosis - trends
Prenatal Diagnosis - methods
Prenatal Diagnosis - trends
Review
筛查
胚胎植入
诊断
遗传分析
遗传学
遗传性疾病
遗传技术
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Summary:Preimplantation genetic diagnosis（PGD） gives couples who have a high risk of transmitting genetic disorders to their baby the chance to have a healthy offspring through embryo genetic analysis and selection.Preimplantation genetic screening（PGS） is an effective method to select euploid embryos that may prevent repeated implantation failure or miscarriage.However,how and to whom PGS should be provided is a controversial topic.The first successful case of PGD of a human being was reported in 1990,and there have been tremendous improvements in this technology since then.Both embryo biopsy and genetic technologies have been improved dramatically,which increase the accuracy and expand the indications of PGD/PGS.
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-014-4683-5