ENDOCRINE FUNCTION IN ALCOHOLIC KORSAKOFF'S SYNDROME

Hypothalamic-pituitary function was studied by means of several dynamic endocrine tests in 19 patients with alcoholic Korsakoff's syndrome, 17 non-amnesic alcoholics and 21 non-alcoholic controls. The responses of thyroid stimulating hormone, prolactin, fofficle stimulating hormone, and luteini...

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Bibliographic Details
Published in:Alcohol and alcoholism (Oxford) 1994-03, Vol.29 (2), p.187-191
Main Authors: EMSLEY, ROBIN A., ROBERTS, MIMI C., AALBERS, COR, TALJAARD, FRANS J. J.
Format: Article
Language:English
Subjects:
Adult
Alcohol Amnestic Disorder - physiopathology
Alcohol Amnestic Disorder - rehabilitation
Alcoholism - physiopathology
Alcoholism - rehabilitation
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Dexamethasone
Female
Follicle Stimulating Hormone - blood
Follow-Up Studies
Gonadotropin-Releasing Hormone
Humans
Hydrocortisone - blood
Hypothalamo-Hypophyseal System - physiopathology
Luteinizing Hormone - blood
Male
Medical sciences
Middle Aged
Pituitary-Adrenal System - physiopathology
Prolactin - blood
Thyrotropin - blood
Thyrotropin-Releasing Hormone
Toxicology
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Summary:Hypothalamic-pituitary function was studied by means of several dynamic endocrine tests in 19 patients with alcoholic Korsakoff's syndrome, 17 non-amnesic alcoholics and 21 non-alcoholic controls. The responses of thyroid stimulating hormone, prolactin, fofficle stimulating hormone, and luteinizing hormone to a combined thyrotropin releasing hormone and gonadoliberin stimulation test did not differ significantly. For the dexamethasone suppression test, the Korsakoff patients had significantly higher basal serum cortisol and 08:00 hr post-dexamethasone cortisol levels than non-alcoholic controls. These findings raise the possibility that chronically elevated cortisol levels may contribute to cognitive impairment in alcoholic Korsakoff's syndrome.
ISSN:0735-0414
1464-3502
1464-3502
DOI:10.1093/oxfordjournals.alcalc.a045506