Combined medico‐surgical strategy for invasive sino‐orbito‐cerebral breakthrough fungal infection with Hormographiella aspergillata in an acute leukaemia patient

Summary Hormographiella aspergillata is a rare causative agent of invasive filamentous breakthrough infection, mostly arising after echinocandin exposure. We report a neutropenic patient who developed a severe sino‐orbito‐cerebral H. aspergillata infection while receiving empirical caspofungin, succ...

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Bibliographic Details
Published in:Mycoses 2015-05, Vol.58 (5), p.308-312
Main Authors: Heiblig, M., Bozzoli, V., Saison, J., Thomas, X., De Croze, D., Traverse‐Glehen, A., Cosmidis, A., Chidiac, C., Ferry, T., Alanio, A., Bienvenu, A. L., Dupont, D., Ducastelle‐Lepretre, S., Michallet, M., Ader, F.
Format: Article
Language:eng ; ger
Subjects:
acute myeloid leukaemia
Agaricales - isolation & purification
allogeneic haematopoietic stem cell transplantation
Antifungal Agents - therapeutic use
basidiomycosis
Brain - microbiology
Brain - pathology
Central Nervous System Fungal Infections - drug therapy
Central Nervous System Fungal Infections - microbiology
Central Nervous System Fungal Infections - surgery
Combined Modality Therapy
Debridement
Drug Resistance, Fungal
Echinocandins - therapeutic use
Fatal Outcome
Hormographiella aspergillata
Humans
Leukemia, Myeloid, Acute - complications
Lipopeptides
Male
Molecular Sequence Data
Neutropenia - complications
Young Adult
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Summary:Summary Hormographiella aspergillata is a rare causative agent of invasive filamentous breakthrough infection, mostly arising after echinocandin exposure. We report a neutropenic patient who developed a severe sino‐orbito‐cerebral H. aspergillata infection while receiving empirical caspofungin, successfully controlled by an aggressive strategy associating surgical debridement and combined high‐dose regimen of antifungal drugs.
ISSN:0933-7407
1439-0507
DOI:10.1111/myc.12305