Human allogeneic AB0/Rh-identical umbilical cord blood cells in the treatment of juvenile patients with cerebral palsy

Abstract Background aims The term “cerebral palsy” (CP) encompasses many syndromes that emerge from brain damage at early stages of ontogenesis and manifest as the inability to retain a normal body position or perform controlled movements. Existing methods of CP treatment, including various rehabili...

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Published in:Cytotherapy (Oxford, England) England), 2015-07, Vol.17 (7), p.969-978
Main Authors: Romanov, Yury A, Tarakanov, Oleg P, Radaev, Sergey M, Dugina, Tamara N, Ryaskina, Svetlana S, Darevskaya, Anna N, Morozova, Yana V, Khachatryan, William A, Lebedev, Konstantin E, Zotova, Nelli S, Burkova, Anna S, Sukhikh, Gennady T, Smirnov, Vladimir N
Format: Article
Language:English
Subjects:
ABO Blood-Group System - immunology
Advanced Basic Science
brain injury
cell therapy
Cell- and Tissue-Based Therapy - methods
cerebral palsy
Cerebral Palsy - therapy
Child
Child, Preschool
Cord Blood Stem Cell Transplantation - methods
Female
Fetal Blood - transplantation
HLA Antigens - immunology
Humans
Infant
Infusions, Intravenous
Male
Other
Rh-Hr Blood-Group System - immunology
Transplantation, Homologous
umbilical cord blood
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Summary:Abstract Background aims The term “cerebral palsy” (CP) encompasses many syndromes that emerge from brain damage at early stages of ontogenesis and manifest as the inability to retain a normal body position or perform controlled movements. Existing methods of CP treatment, including various rehabilitation strategies and surgical and pharmacological interventions, are mostly palliative, and there is no specific therapy focused on restoring injured brain function. Methods During a post-registration clinical investigation, the safety and efficacy of intravenous infusion of allogeneic human leukocyte antigen (HLA)-unmatched umbilical cord blood (UCB) cells were studied in 80 pediatric patients with cerebral palsy and associated neurological complications. Patients received up to 6 intravenous infusions of AB0/Rh-identical, red blood cell–depleted UCB cells at an average dose of 250 × 106 viable cells per infusion. Results Patients were followed for 3–36 months, and multiple cell infusions did not cause any adverse effects. In contrast, in most patients who received four or more UCB cell infusions, positive dynamics related to significant improvements in neurological status and/or cognitive functions were observed. Conclusions The results confirm that multiple intravenous infusions of allogeneic AB0/Rh-identical UCB cells may be a safe and effective procedure and could be included in treatment and rehabilitation programs for juvenile patients with cerebral palsy.
ISSN:1465-3249
1477-2566
DOI:10.1016/j.jcyt.2015.02.010