Listerial brainstem encephalitis--treatable, but easily missed

Listerial brainstem encephalitis (LBE) is an uncommon form of listerial central nervous system infection that progresses rapidly and is invariably fatal unless detected and treated early. We report on six adult patients with LBE, of whom five were managed or co-managed by our unit during the period...

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Bibliographic Details
Published in:South African medical journal 2015-01, Vol.105 (1), p.17-20
Main Authors: Fredericks, P, Britz, M, Eastman, R, Carr, J A, Bateman, K J
Format: Article
Language:English
Subjects:
Adult
Analysis
Blood
Brain Stem - microbiology
Brain Stem - physiopathology
C-Reactive Protein - metabolism
Care and treatment
Diagnosis
Diagnostic errors
Disease Progression
Encephalitis
Encephalitis - diagnosis
Encephalitis - microbiology
Encephalitis - therapy
Female
Humans
Listeriosis - diagnosis
Listeriosis - microbiology
Listeriosis - therapy
Magnetic Resonance Imaging - methods
Male
Medical examination
Middle Aged
Prodromal Symptoms
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Summary:Listerial brainstem encephalitis (LBE) is an uncommon form of listerial central nervous system infection that progresses rapidly and is invariably fatal unless detected and treated early. We report on six adult patients with LBE, of whom five were managed or co-managed by our unit during the period January - June 2012. All presented with a short prodromal illness followed by a combination of brainstem signs, including multiple cranial nerve palsies with emphasis on the lower cranial nerves, ataxia, motor and sensory long-tract signs, a depressed level of consciousness and apnoea. In two cases the diagnosis was delayed with adverse outcomes. LBE may be difficult to diagnose: clinicians may not be aware of this condition, the brainstem location may not be recognised readily, general markers of inflammation such as the erythrocyte sedimentation rate, C-reactive protein level or white cell count may be normal, and the cerebrospinal fluid is typically normal or there are only mild and nonspecific findings. Serological tests are unreliable, and diagnosis is achieved through blood cultures, magnetic resonance imaging and clinical recognition.
ISSN:0256-9574
DOI:10.7196/SAMJ.8700