Comparative analysis reveals loss of the appetite-regulating peptide hormone ghrelin in falcons

Highlights • Compared GHRL , which encodes the appetite regulator ghrelin, of 31 bird species. • No canonical GHRL start-codon in peregrine and saker falcons. • Retrotransposon inserted in intron 0 of falcon GHRL. • Ghrelin is anorexigenic in birds and loss could be a predatory adaptation in falcons...

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Bibliographic Details
Published in:General and comparative endocrinology 2015-05, Vol.216, p.98-102
Main Authors: Seim, Inge, Jeffery, Penny L, Herington, Adrian C, Chopin, Lisa K
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Appetite Regulation - physiology
Birds
Endocrinology & Metabolism
Evolution
Falconiformes - physiology
Ghrelin
Ghrelin - metabolism
Molecular Sequence Data
Peptide hormone
Peptide Hormones - metabolism
Phylogeny
Retrotransposon
Sequence Homology, Amino Acid
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Summary:Highlights • Compared GHRL , which encodes the appetite regulator ghrelin, of 31 bird species. • No canonical GHRL start-codon in peregrine and saker falcons. • Retrotransposon inserted in intron 0 of falcon GHRL. • Ghrelin is anorexigenic in birds and loss could be a predatory adaptation in falcons.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2014.11.016